多巴胺D1类受体对Ox-LDL诱导的巨噬细胞增殖的影响

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1、第三军医大学硕士学位论文缩略语表英文缩写英文全称中文全称AKT(PKB)ProteinKinaseB蛋白激酶BASAtherosclerosis动脉粥样硬化BSABovineserumalbumin牛血清白蛋白BpBasepair碱基对cDNAComplementaryDNA脱氧核糖核酸D1DopamineD1-likereceptor多巴胺D1类受体D5DopamineD5receptor多巴胺D5受体DABDiaminobenzidine二氨基联苯胺DAGDiacylglycerol二酯酰甘油DEPCDiethylpyrocarbonate二乙基焦碳酸盐D

2、MSODimethylsulfoxide二甲基亚砜DNADeoxyribonucleicacid脱氧核糖核酸EDTAEthylendiaminotertracetic乙二胺四乙酸ERKExtracellularregulatedproteinkinases细胞外调节蛋白激酶FenFenoldopam非诺多泮FBSFetalbovineserum胎牛血清GM-CSFGranulocyte-macrophagecolonystimulating粒细胞-巨噬细胞集落刺激factor因子HHour小时H2O2Hydrogenperoxide过氧化氢HepesN-2-h

3、ydroxyethylpiperaine-N/-2-ethanesμlfonicN-2-羟乙基哌嗪-N/-2-乙磺acid酸IP3Inositoltriphosphate三磷酸肌醇KDKilo-doltons千道尔顿LLiter升mRNAMessengerRibonucleicacid信使核糖核酸1万方数据第三军医大学硕士学位论文MAPKMitogen-activatedproteinkinase丝裂素活化蛋白激酶MMole/liter摩尔/升MinMinute分钟NCNitrocellulose硝酸纤维素NONitricoxide一氧化氮Ox-LDLOxid

4、izedlowdensitylipoprotein氧化低密度脂蛋白PAGEPolyacrylamidegelelectrophoresis聚丙烯酰胺凝胶电泳PD98059InhibitorofMAPKsMAPK/ERK抑制剂PMSFPhenylmethylsulfonylfluoride苯甲基磺酰氟PBSPhosphatebuffersolution磷酸盐生理盐水缓冲液PI3KPhosphatidylinositol3-kinase磷脂酰肌醇-3-激酶PKCProteinkinaseCsystem蛋白激酶CPLCPhospholipaseC磷脂酶CPCRPol

5、ymerase-chain-reaction聚合酶链反应PDGFPlatelet-derivedgrowthfactor血小板来源生长因子RAW264.7RAW264.7CellLine(Murine)小鼠单核巨噬细胞系RNARibonucleicacid核糖核酸RTReversetranscription核糖核酸逆转录反应SDSSodiumdodecylsulfate十二烷基硫酸钠TEMEDTetramethylethylenediamine四甲基二乙胺TBSTTriethanolamine-bufferedsalinewithtween三乙醇胺缓冲盐Tri

6、s-HClTrishydrochloricacidbuffersolutionTris-盐酸缓冲液THP-1HumanTHP-1monocytes人单核巨噬细胞系μgMicrogram微克μlMicroliter微升℃Centigrade摄氏度2万方数据第三军医大学硕士学位论文DopamineD1-likeReceptorsSuppressestheProliferationofMacrophagesInducedbyOx-LDLAbstractBackground:Atherosclerosis(AS)isthemainpathologyofheartand

7、cerebrovasculardiseases.Thedamageofendothelialcells,thepathologicalphysiologicalprocessofmonocytes,vascularsmoothmusclecells(VSMCs)andmacrophagesmigration,proliferationandthereleaseofinflammatorycytokinesandsoonarebelievedtobethemajorpathophysiologicalprocessesofatherosclerosis.Macr

8、ophagesphagocyteche