还原敏感性壳交联药物载体的制备与其在药物控释上的应用分析

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1、浙江理工人学硕士学位论文PreparationofRedox-SensitiveShellCross-linkedCarriersforControlledReleaseofBioactiveAgentsABSTRACTNanocarriersobtainedfromself-assemblyofamphiphilicblockeopolymersinaqueoussolutionhavebeenwellinvestigatedinthepastdecades．However,intheprac

2、ticalapplications，thestabilityofnanocarriersisofgreatchallengesincetheywoulddisassembleuponstimulationssuchaspH，temperature，etc．Thecorecross-linkedorshellcrOSS—linkedapproacheshavebeendevelopedtomaintaintheirstructuralintegrity．Thisdissertationmainly

3、focusesonfabricationofredox·-sensitiveshellcrOSS-linkednanocarriersvia(inverse)miniemulsionreversibleaddition-fragmentationchaintransfer(RAFT)polymerization．Thisdissertationincludesfourpartsasfollowing：1．ShellcrOSS-linkedpoly(2-(dimethylamino)ethylme

4、thacrylate)-b—polystyrene(PDMAEMA-b-PS)nanoparticleswerepreparedinaminiemulsionRAFTsystem，inwhichPDMAEMARAFTchaintransferagentsactedasstabilizers．Theamountofthecross-linkerWasallinfluenceparameteronthemorphology．Thediameterofnanoparticlesincreasedwit

5、haconcomitantincreasinginamountofthecrOSS-linker．Andtheas—preparedshellcrOSS-linkednanopartilceshadaninherentfluorescentproperty．Sotheycallbedirectlyusedasadrugdeliverycarrier伽vivowithoutanyfluorescencelabelingtreatments．2．Whentheamountofcross—linker

6、Wasrelativelow,theshellCROSS．1inkedPDMAEMA--b·-PSnanoparticlesunderwentafissionprocessduringtheminiemulsionRAFTpolymerizationprocess．Thefissionwasinducedbythedifferentratebetweenthemonomertransferandthepolymerization／nsitu，alongwiththedifferencesinth

7、ermalexpansivityofthemonomersandthePDMAEMARAFTchaintransferagents．3．ShellcrOSS—linkedpoly(2-(dimethylamino)ethylmethacrylate)-b-poly(methylacrylicacid)(PDMAEMA-b-PMaA)nanocapsuleswerepreparedinaninverseminiemulsionRAFTsystem，inwhichPDMAEMARAFTchaintr

8、ansferagentsactedasstabilizers．Theas—preparednanocapsuleshadwelldefinitecore-shellstructuresandcouldbeusedasacarriertoencapsulatesodiumchloride．TheshellcrOSS—linkednanocapsulesCanbedegradedintodiblockcopolymersaftertheadditionoftheredox-reagentdithio