中西医结合治疗特应性皮炎的临床观察

《中西医结合治疗特应性皮炎的临床观察》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、维普资讯http://www.cqvip.com·686·合杂志2008年8月第28卷第8期CJITWM．August2008．v01．28．No．8中西医结合治疗特应性皮炎的临床观察史永俭张春敏马冬梅刘瑛张冬云张春红魏国孟丽亚摘要目的观察中西医结合治疗特异性皮炎的临床疗效及其作用机制。方法将47例特异性皮炎患者随机分为中西医结合组和西药组。西药组单纯口服氯雷他定10mg，每天1次。中西医结合组在西药组治疗基础上合并加味当归饮加减治疗，疗程4周。并用双抗体夹心ELISA法检测两组患者治疗前后外周血白细胞介素4、

2、10、12(IL一4、IL一10、IL一12)水平。结果中西医结合组愈显率56％(14／25例)，西药组为22．7％(5／22例)，两组比较，差异有统计学意义(x=5．38，P<0．05)。治疗前两组患者与健康对照组比较，IL一4、10水平升高，IL一12水平降低(均P<0．01)；治疗后中西医结合组3种细胞因子水平恢复正常，西药组无明显变化。两组比较，差异有统计学意义(P<0．01)。结论中西医结合治疗特应性皮炎疗效肯定，其作用机制可能与调节相关细胞因子水平有关。关键词特应性皮炎；细胞因子；中西医结合Clin

3、icalStudyonTreatmentofAtopicDermatitisbyIntegratedTraditionalChineseandWesternMedicineSHIYong-jian，ZHANGChun—min，MADong—mei，etalTheSecondHospitalofShandongUniversity，。^凡n凡(250033)AbstractObjectiveToobservetheclinicaleffectsandexplorethemechanismoftheintegrat

4、edtraditionalChineseandWesternmedicineintreatingatopicdermatitis(AD)．MethodsForty—sevenpatientswithADwererandomlyassignedtotwogroups，thecontrolgroupandthetreatedgroup，theyweretreatedwithconventionalWesternmedicine(10mgLoratadinetablet，oncedaily)andwithintegr

5、atedmedicineadditionallygivenmodifiedJiaweiDangguiDecectionbesidesWesternmedicinerespectivelyfor4weeks．Double—sandwichELISAwasusedtodetectthelevelsofinterleukin一4，一10and一12(IL一4，IL一10andIL一12)beforeandaftertreatment．ResultsThetotaleffectiverateinthetreatedgr

6、oupwas56％(14／25cases)，betterthanthatinthecontrolgroup(22．7％，5／22cases)，showingsignificantdifferencebetweenthetwogroups(x=5．38，P<0．05)．Beforetreatmenttheser—amlevelsofIL一4，IL一10weresignificantlyhigherandlevelofIL一12waslowerinADpatientsascomparedwiththoseinhea

7、lthypersons(P<0．01)；theyallrestoredtonormalinthetreatedgroupaftertreatmentbutunchangedinthecontrolgroup，showingsignificantdifferencebetweenthetwogroups(P<0．01)．ConclusionTheclinicaleffectofintegratedtraditionalChineseandWesternmedicineisascertainable，itsmech

8、anismmightbeassociatedwiththeregulationonrelatedcytokines．Keywordsatopicdermatitis；cytokine；integratedtraditionalChineseandWesternmedicine特应性皮炎(atopicdermatitis，AD)是临床上常见临床资料的慢性、瘙痒性、炎症性皮肤病，常有血管舒