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1、ProceedingsoftheNutritionSociety(2014),73,413–421doi:10.1017/S0029665114000081©TheAuthors2014Firstpublishedonline21March2014TheNutritionSocietyAnnualSummerMeetingwasheldatNewcastleUniversityon15–18July2013Conferenceon‘Nutritionandhealthyageing’Symposium1:Biologyofagei
2、ngDNAmethylation,ageingandtheinfluenceofearlylifenutrition1222KarenA.Lillycrop*,SamuelP.Hoile,LeonieGrenfellandGrahamC.Burdge1FacultyofNaturalandEnvironmentalSciences,CentreforBiologicalSciences,UniversityofSouthampton,Southampton,UK2AcademicUnitofHumanDevelopmentandHe
3、alth,FacultyofMedicine,UniversityofSouthampton,Southampton,UKItiswellestablishedthatgenotypeplaysanimportantroleintheageingprocess.However,recentstudieshavesuggestedthatepigeneticmechanismsmayalsoinfluencetheonsetofageing-associateddiseasesandlongevity.Epigeneticsisdefi
4、nedasprocessesthatinduceheritablechangesingeneexpressionwithoutachangeintheDNAnucleotidesequence.ThemajorepigeneticmechanismsareDNAmethylation,histonemodificationandnon-codingRNA.Suchprocessesareinvolvedintheregulationoftissue-specificgeneexpression,celldifferentiationa
5、ndgenomicimprinting.However,epigeneticdysregulationisfrequentlyseenwithageing.Relativelylittleisknownaboutthefactorsthatinitiatesuchchanges.However,thereisemergingevidencethattheearlylifeenvironment,inpar-ticularnutrition,inearlylifecaninducelong-termchangesinDNAmethy
6、lationresultinginanalteredsusceptibilitytoarangeofageing-associateddiseases.Inthisreview,wewillfocusonthechangesinDNAmethylationthatoccurduringageing;theirroleintheageingprocessandhowearlylifenutritioncanmodulateDNAmethylationandinfluencelongevity.Understandingthemecha
7、nismsbywhichdietinearlylifecaninfluencetheepigenomewillbecrucialforthedevelopmentofpreventativeandinterventionstrategiestoincreasewell-beinginlaterlife.Epigenetics:DNAmethylation:Ageing:Developmentaloriginsofadultdisease:NutritionProceedingsoftheNutritionSocietyAgeingi
8、stheaccumulationofchangeswithinanorgan-Epigeneticmechanismsismthatresultinareducedstressresponse,impairedhomeostasis,aneleva
