9781849737623-00225

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1、RecentdevelopmentsinthedesignofnanomaterialsforphotothermalandmagnetichyperthermiainducedcontrollabledrugdeliveryaaabAlexanderE.Dunn,DouglasJ.Dunn,MayLim,*CyrilleBoyercandNguyeˆ˜nThiKimThanhDOI:10.1039/9781849737623-00225Recentdevelopmentsinanti-cancerdrugsarefocusedonminimisingsideeffectsandimpr

2、ovingtreatmentefficacy.Thiscanbeachievedbyusingacarrierthatreleasesthedruginresponsetoastimulus.Inrecentyears,researchhasbeendirectedtowardstheuseoflightoralternatingmagneticfieldsasremotestimuliinwhatiscalledphotothermalandmagnetichyperthermiainducedcontrollabledrugdelivery,respectively.Muchprogre

3、sshasalsobeenmadeintheuseofnanoparticlesandpolymericmacromoleculesasdrugcarriers.Bycombiningpolymerswithinorganicnanoparticlesintoasingleentity,itbecomespossibletoharnessthelightormagneticfieldresponsivepropertiesofnanoparticleswiththedrugstorageandreleasepropertiesofpolymersfordrugdelivery.Inthi

4、sreview,weexplorerecentdevel-opmentsofpolymer-nanoparticlehybridsdrugcarriersforphotothermalandmagnetichyperthermiacontrollabledrugdelivery.1IntroductionRecentimprovementsincancertreatmenthaveresultedinanincreaseinpost-diagnosislifeexpectancy.Theseimprovementswereenabledbythedevelopmentofpotentt

5、herapeuticagentswithnovelmodesofaction.Nonetheless,duetotheirinherenttoxicity,manyofthesetherapeuticagentsDownloadedbyUniversityofIllinois-Urbanaon23/01/201404:19:08.arelimitedbythedosethatcanbesafelydeliveredwithoutcausingdebili-Publishedon31December2013onhttp://pubs.rsc.org

6、doi:10.1039/9781849

7、737623-00225tatingsideeffects.Inaddition,asystemicrouteofadministrationoftenresultsinanarrowtherapeuticwindowsuchthatprolongedexposuretothetherapeuticagentisrequiredinordertoachievesufficienttreatmentefficacy.Thismayleadtoindiscriminatecytotoxicityofthetherapeuticagenttowardnormalandcancercellsthroug

8、houtthebody,resultinginseveresideeffectssuchasimmunosuppressionandorganfailureinthepatient.Ananomaterialbasedcontrollabledrugdeliveryplatformwouldover-comemanyofthemajordrawbacksincancertherapy.Thesenanocarriersstorethetherap