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1、REVIEWSPerspectivesandopportunitiesfornanomedicineinthemanagementofatherosclerosisMarkE. Lobatto*‡,ValentinFuster§
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3、,ZahiA. Fayad*andWillemJ. M. Mulder*‡Abstract
4、Theuseofnanotechnologyformedicalpurposes—nanomedicine—hasgrownexponentiallyoverthepastfewdecades.Thisise
5、xemplifiedbytheUSFoodandDrugAdministration’sapprovalofseveralnanotherapiesforvariousconditions,aswellasthefundingofnanomedicalprogrammesworldwide.Althoughoriginallythedomainofanticancertherapy,recentadvanceshaveillustratedtheconsiderablepotentialofnanomedicineinthed
6、iagnosisandtreatmentofatherosclerosis.ThisReviewelaboratesonnanoparticle-targetingconceptsinatheroscleroticdisease,providesanoverviewoftheuseofnanomedicineinatherosclerosis,anddiscussespotentialfutureapplicationsandclinicalbenefits.Nanomedicinehasbeendefinedas“appli
7、cationsofOneofthefirstclinicallyapprovednanomedicinalnanotechnologyfortreatment,diagnosis,monitoring,therapieswasaliposomalformulationofdoxorubicin,andcontrolofbiologicalsystems”1.Theseapplicationsacytotoxicdrugusedforcancerchemotherapy.This*TranslationalandMolecula
8、rrangefromtargetedtherapy,in vivoimagingandformulation,brandedDoxil,wasapprovedbytheUSImagingInstitute,Mountin vitrodiagnosticstobiomaterialsandactiveimplants2.FoodandDrugAdministrationin1995forthetreatmentSinaiSchoolofMedicine,Nanoparticles,whicharetypicallyinthera
9、ngeofofKaposi’ssarcomaandlaterapprovedforothercancerOneGustaveL.LevyPlace,BOX 1234,NewYork1–100nminsize,aresimilarinscaletobiologicalmac-types.Subsequently,severalothernanomedicinal10029,USA.romoleculessuchasproteinsandDNA3.Importantly,therapeuticshavebeenapprovedas
10、anticancertreat-‡DepartmentofVascularintrinsicphysicalpropertiesofmaterialsatthislevelmayments,includingliposomaldaunorubicin(DaunoXome;Medicine,AcademicMedicalchange,providingfundamentallydifferentpropertiesGileadSciences),appliedinpatientswithadvancedCenter,Meiber
11、gdreef9,fromthebulkmaterial4.NanoparticlescanbecomposedHIV-relatedKaposi’ssarcoma,andanalbumin-bound1105AZ,Amsterdam,TheNetherlands.oforga
