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1、ªSpringerScience+BusinessMedia,LLC2011AbdomImaging(2011)AbdominalDOI:10.1007/s00261-011-9683-3ImagingINVITEDFEATURESECTIONAssessmentofthetreatmentresponseofHCC111,2KyungWonKim,JeongMinLee,ByungIhnChoi1DepartmentofRadiology,SeoulNationalUniversityHospital,101Daehangno,Jongno-gu,Seou
2、l110-744,Korea2InstituteofRadiationMedicine,SeoulNationalUniversityHospital,101Daehangno,Jongno-gu,Seoul110-744,KoreaAbstractHCCandlivercirrhosis(LC)becauseofthehighriskofrecurrentHCCinthenativecirrhoticliver.However,theSurgicalhepatectomyorlivertransplantationarecon-internationals
3、hortageofliverdonors,thestrictpatientsideredascurativetreatmentmodalitiesforhepatocel-selectioncriteria,andthehighcostofsurgicalprocedurelularcarcinoma(HCC).However,manypatientsarenotlimitsthepracticaluseoflivertransplantation[2].Cur-surgicalcandidatesatthetimeofdiagnosis.Greatrent
4、ly,thereportedoverall5-yearpatientsurvivalafterimprovementsinlocoregionaltherapiesincludinglocalresectionofHCCis40%–70%withacontinuingdecreaseablativetherapy[radiofrequency(RF)ablationoretha-inoperativemortality[3].Unfortunately,only10%–30%nolablation]andtransarterialtechniques(tra
5、nsarterialofHCCsareamenableto‘‘curative’’surgicalresectionatembolizationortransarterialradioembolization)havethetimeofdiagnosisbecauseadvanceddiseasewithmadepossiblelocalcontrolofHCC.Forunresectableintrahepaticorextrahepatictumorspread,grossvascularHCC,atargetedtherapywithsorafenib
6、mayimproveinvasionorinadequatefunctionalliverreserverelatedtosurvival.Unliketreatmentofotheroncologictumor,theco-existentcirrhosisprecludessuccessfulsurgery[4].Inlocoregionaltherapiesaremainstayinthetreatmentofthepastyears,greatimprovementsinlocoregionalHCC.Therefore,theapplication
7、ofclassicalcriteriasuchtherapies,includinglocalablativetherapy[radiofre-astheWorldHealthOrganization(WHO)guidelinemayquency(RF)ablation,ethanolablationorcryotherapy]notbesuitableforaccuratetreatmentresponseassess-andtransarterialtechniques(transarterialchemoembo-mentoflocoregionalt
8、herapiesortargetedtherapyo
