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1、CurrentDrugDelivery,2012,9,305-314305Rutin-PhospholipidComplex:AnInnovativeTechniqueinNovelDrugDeliverySystem-NDDS11,22DevendraSingh,M.S.M.Rawat*,AjaySemaltyandMonaSemalty12DepartmentofChemistry,HNBGarhwalUniversity,Srinagar(Garhwal)246174,Uttarakhand,India;Depa
2、rtmentofPharmaceuticalSciences,HNBGarhwalUniversity,Srinagar(Garhwal)246174,Uttarakhand,IndiaAbstract:Biopharmaceuticalpropertiestogetherwithpotencycontributecriticallytowardsclinicalefficacyofthedrugsbyinfluencingthedissolutionandbioavailability.Theaimofthisstu
3、dywastodevelopanamphiphilicphyto-phospholipidcom-plexinordertoenhancethedeliveryofpoorlysolublerutin.Therutin-phospholipidcomplex(Ru-PLc)waspreparedandin-vestigatedforvariousphysico-chemicalparameterslikedrugloading,infraredabsorption(FTIR),differentialscanningc
4、alo-rimetry(DSC),X-raypowderdiffractometry(XRPD),scanningelectronmicroscopy(SEM),aqueous/n-octanolsolubilityanddissolutionstudy.Theinvitroanti-oxidantactivitywasalsostudied.IntheSEM,Ru-PLcwasfoundfluffyandporouswithroughsurfacemorphology.FTIR,DSCandXRPDdataconfi
5、rmedtheformationofphospholipidcomplex.Thewater/n-octanolsolubilityofrutinwasimprovedfrom2.88to45.71μg/mland68.17to245.18μg/ml,respectivelyinthecomplex.TheimproveddissolutionwasshownbythephospholipidcomplexatdifferentpHbuffers.Theantioxidantactivityindicatedthat,
6、thebioactivityofrutinwasmaintainedevenafterbeingcomplexedwiththephospholipid.Basedontheresults,itcanbeconcludedthatthephospholipidcomplexmaybeconsideredasapromisingdrugdeliverysystemforimprovingtheoverallabsorptionandbioavailabilityoftherutinmolecule.Keywords:Ru
7、tin,Phosphatidylcholine,Phospholipidcomplex,Chromatographicanalysis,DSC,X-RPD,Antioxidantassay.1.INTRODUCTIONbarriers.Phosphatidylcholine(PC)isnotonlyapassivecar-rierforthephytochemicalsbutalsoabioactivenutrientwithDrugdeliveryisarapidlydevelopingandevolvingdisc
8、i-documentedclinicalefficacyforliverdiseases,includingplinebytheprinciplesanddevelopmentinrelatedfieldsalcoholichepaticsteatosis,drug-inducedliverdamageandfromclassic
