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1、Thenewenglandjournalofmedicineestablishedin1812august11,2011vol.365no.6PreventionofHIV-1InfectionwithEarlyAntiretroviralTherapyMyronS.Cohen,M.D.,YingQ.Chen,Ph.D.,MarybethMcCauley,M.P.H.,TheresaGamble,Ph.D.,MinaC.Hosseinipour,M.D.,NagalingeswaranKumarasamy,M.B.,B.S.,Jame
2、sG.Hakim,M.D.,JohnstoneKumwenda,F.R.C.P.,BeatrizGrinsztejn,M.D.,JoseH.S.Pilotto,M.D.,SheelaV.Godbole,M.D.,SanjayMehendale,M.D.,SuwatChariyalertsak,M.D.,BrenoR.Santos,M.D.,KennethH.Mayer,M.D.,IrvingF.Hoffman,P.A.,SusanH.Eshleman,M.D.,EstellePiwowar-Manning,M.T.,LeiWang,P
3、h.D.,JosephMakhema,F.R.C.P.,LisaA.Mills,M.D.,GuydeBruyn,M.B.,B.Ch.,IanSanne,M.B.,B.Ch.,JosephEron,M.D.,JoelGallant,M.D.,DianeHavlir,M.D.,SusanSwindells,M.B.,B.S.,HeatherRibaudo,Ph.D.,VanessaElharrar,M.D.,DavidBurns,M.D.,TahaE.Taha,M.B.,B.S.,KarinNielsen-Saines,M.D.,Davi
4、dCelentano,Sc.D.,MaxEssex,D.V.M.,andThomasR.Fleming,Ph.D.,fortheHPTN052StudyTeam*AbstractBackgroundAntiretroviraltherapythatreducesviralreplicationcouldlimitthetransmissionofTheauthors’affiliationsarelistedinthehumanimmunodeficiencyvirustype1(HIV-1)inserodiscordantcoupl
5、es.Appendix.AddressreprintrequeststoDr.CohenattheUniversityofNorthCarolinaMethodsatChapelHill,InstituteforGlobalHealthandInfectiousDiseases,Suite2115,Bio-Inninecountries,weenrolled1763couplesinwhichonepartnerwasHIV-1–positiveinformaticsBldg.,130MasonFarmRd.,andtheotherw
6、asHIV-1–negative;54%ofthesubjectswerefromAfrica,and50%CB7030,ChapelHill,NC27599,oratofinfectedpartnersweremen.HIV-1–infectedsubjectswithCD4countsbetweenmscohen@med.unc.edu.350and550cellspercubicmillimeterwererandomlyassignedina1:1ratiotoreceive*OthermembersoftheHIVPreve
7、ntionantiretroviraltherapyeitherimmediately(earlytherapy)orafteradeclineintheCD4TrialsNetwork(HPTN)052StudyTeamcountortheonsetofHIV-1–relatedsymptoms(delayedtherapy).Theprimarypreven-arelistedintheSupplementaryAppen-dix,availableatNEJM.org.tionendpointwaslinkedHIV-1tran
8、smissioninHIV-1–negativepartners.Thepri-maryclinicalendpointwastheearliestoccurrenceofpulmonarytuberculosis,se
