Bioelectrical-impedance-phase-angle-relates-to-function-disease-severity-and-prognosis-in-stable-chronic-obstructive-pulmonary-disease_2015_Clinical-N

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1、ClinicalNutrition34(2015)1245e1250ContentslistsavailableatScienceDirectClinicalNutritionjournalhomepage:http://www.elsevier.com/locate/clnuOriginalarticleBioelectricalimpedancephaseanglerelatestofunction,diseaseseverityandprognosisinstablechronicobstructive

2、pulmonarydiseasea,b,*bbbMatthewMaddocks,SamanthaS.C.Kon,SarahE.Jones,JaneL.Canavan,baabbClaireM.Nolan,IreneJ.Higginson,WeiGao,MichaelI.Polkey,WilliamD.-C.ManaKing'sCollegeLondon,CicelySaundersInstitute,London,UKbNIHRRespiratoryBiomedicalResearchUnit,RoyalBr

3、omptonandHarefieldNHSFoundationTrustandImperialCollege,London,UKarticleinfosummaryArticlehistory:Background&aims:Bioelectricalimpedanceanalysis(BIA)providesasimplemethodtoassesschangesReceived23October2014inbodycomposition.RawBIAvariablessuchasphaseangleprov

4、idedirectinformationoncellularmassAccepted29December2014andintegrity,withouttheassumptionsinherentinestimatingbodycompartments,e.g.fat-freemass(FFM).Phaseangleisastrongfunctionalandprognosticmarkerinmanydiseasestates,butdatainCOPDKeywords:arelacking.Ouraims

5、weretodescribethemeasurementofphaseangleinpatientswithstableCOPDandBodycompositiondeterminetheconstructanddiscriminatevalidityofphaseanglebyassessingitsrelationshipwithBioelectricalimpedanceanalysisestablishedmarkersoffunction,diseaseseverityandprognosis.Ch

6、ronicobstructivepulmonarydiseaseMethods:502outpatientswithstableCOPDwerestudied.PhaseangleandFFMbyBIA,quadricepsFat-freemassPhaseanglestrength(QMVC),4-mgaitspeed(4MGS),5sit-to-standtime(5STS),incrementalshuttlewalk(ISW),andcompositeprognosticindices(ADO,iBO

7、DE)weremeasured.PatientswerestratifiedintonormalandlowphaseangleandFFMindex.Results:PhaseanglecorrelatedpositivelywithFFMandfunctionaloutcomes(r¼0.35e0.66,p<0.001)andnegativelywithprognosticindices(r¼0.35to0.48,p<0.001).Inregressionmodels,phaseanglewasinde

8、pendentlyassociatedwithISW,ADOandiBODEwhereasFFMwasremoved.Onehundredandseventypatients(33.9%[95%CI,29.9e38.1])hadalowphaseangle.PhenotypiccharacteristicsincludedlowerQMVC,ISW,and4MGS,higher5STS,ADOand