primer on molecular biology

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1、PrimeronMolecularGenetics1DOEHumanGenomeProgramPrimeronMolecularGeneticsDatePublished:June1992U.S.DepartmentofEnergyOfficeofEnergyResearchOfficeofHealthandEnvironmentalResearchWashington,DC20585The"PrimeronMolecularGenetics"istakenfromtheJune1992DOEHumanGenome1991-92ProgramReport.Theprimer

2、isintendedtobeanintroductiontobasicprinciplesofmoleculargeneticspertainingtothegenomeproject.HumanGenomeManagementInformationSystemOakRidgeNationalLaboratory1060CommerceParkOakRidge,TN37830Voice:865/576-6669Fax:865/574-9888E-mail:bkq@ornl.gov2ContentsPrimeronMolecularIntroduction..........

3、...................................................................................................5GeneticsDNA...............................................................................................................................6Genes..............................................

4、..............................................................................7RevisedandexpandedChromosomes...............................................................................................................8byDeniseCasey(HGMIS)fromtheMappingandSequencingtheHumanGenome.........

5、.............................10primercontributedbyCharlesCantorandMappingStrategies.....................................................................................................11SylviaSpenglerGeneticLinkageMaps........................................................................

6、....................11(LawrenceBerkeleyPhysicalMaps.........................................................................................................13Laboratory)andLow-ResolutionPhysicalMapping......................................................................14publishedintheChr

7、omosomalmap.........................................................................................14HumanGenome1989–cDNAmap......................................................................................................1490ProgramReport.High-Resolution