Antigen receptor signaling_653406373

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1、Signalingthroughimmunesystem(antigen)receptorsJaneway’sImmunobiology7thEd.Chapter6Outline•Generalprinciplesofsignalingcommunication•Tcellreceptorsignaling•Signalingbasisforco-stimulationanditsconceptualimplicationsSignalingtransduction:why?•Receptoreffectorfunctions•Outsidereceptor……cytoplas

2、mand/ornucleusFigure15-6MolecularBiologyoftheCell(©GarlandScience2008)AlteredT/Bcellbehaviors(Immunologicalfunctions)•Examples?Figure15-1MolecularBiologyoftheCell(©GarlandScience2008)回忆回忆回忆AntigenpresentationActionofcytokinesFormsofIntercellulardeliveryofsignalsAntigenpres.&cytokinesFigure15-4Mo

3、lecularBiologyoftheCell(©GarlandScience2008)IntegrationofsignalsFigure15-8MolecularBiologyoftheCell(©GarlandScience2008)Two(three)-signalmodelfornaïveTcellsThreelargestclassesofsurfacereceptorsFigure15-16MolecularBiologyoftheCell(©GarlandScience2008)形式:目的:CascadeIntegrationPathwayAmplificationNet

4、workBranchingFigure15-17MolecularBiologyoftheCell(©GarlandScience2008)AmplificationTyrosineSerineSwitchThreonineFigure15-18MolecularBiologyoftheCell(©GarlandScience2008)RegulationofsmallGproteinGuaninenucleotideExchangeFactorGTPaseActivatingProteinFigure15-19MolecularBiologyoftheCell(©GarlandScie

5、nce2008)Down-modulationSignalingthroughmolecularinteractions:location,location…•Preformedcomplexbyscaffolding•Complexassemblyuponreceptoractivation–Proteinscaffold–Lipid•InteractiondomainsFigure15-21aMolecularBiologyoftheCell(©GarlandScience2008)Signalingthroughmolecularinteractions•Preformedcom

6、plexbyscaffolding•Complexassemblyuponreceptoractivation–Proteinscaffold–Lipid•InteractiondomainsFigure15-21bMolecularBiologyoftheCell(©GarlandScience2008)Figure15-21cMolecularBiologyoftheCell(©GarlandScience2008)Signalingthroughmolecularinteractions•Preformedcomplexbyscaffolding•Complexassemblyu

7、ponreceptoractivation–Proteinscaffold–Lipid•InteractiondomainsFigure15-22MolecularBiologyoftheCell(©GarlandScience2008)Membranedomains:organizationofsignalingcomponentsatalargerscale回忆AntigenreceptorsofBandTcellsNon-signalin