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1、SendOrdersforReprintstoreprints@benthamscience.aeCurrentAgingScience,2015,8,147-157147CellularAging,SenescenceandAutophagyProcessesinOsteoarthritisMohamedBenderdour,JohanneMartel-Pelletier,Jean-PierrePelletier,MohitKapoor,Maria-VictoriaZunzuneguiandHassanFahmi*OsteoarthritisResearchUnit,Universityo
2、fMontrealHospitalResearchCenter(CRCHUM),900,rueSaint-Denis,Montreal,Quebec,CanadaAbstract:Osteoarthritis(OA)isthemostcommonformofarthritisandahugehealthandfinancialburden.TheprevalenceandincidenceofOAarelikelytoriseduetoincreasinglifeexpectancy.Al-thoughthelinkbetweenagingandOAiswellestablished,lit
3、tleisknownaboutthemechanismsbywhichagingcontributestoOAdevelopment.Inrecentyears,progresshasbeenmadeinunderstandingthemolecularmechanismsofchondrocyteagingandsenescence.Agingandsenescentchondrocytesdisplayasenescence-associatedsecretoryphenotype(SASP)associatedwithincreasedsecretionofpro-inflammato
4、rymediators,extracellularmatrixdegradingenzymesandoxidativestress,allofwhichcancontributetothedevelopmentandprogressionofOA.Thereisalsoevidencethatautophagy,anessentialhomeostaticprocess,declineswithagingandduringOA.Thisreviewwillfocusonourcurrentunderstandingofchondrocyteaging,senescence,andautoph
5、agyandtheirpotentialrolesinthedevelopmentandprogressionofOA.AnunderstandingoftheseprocesseswouldbeveryusefulindevisingstrategiestotreatOAortodelayitsdevelopment.Keywords:Aging,autophagy,chondrocytes,osteoarthritis,senescence.INTRODUCTIONbeingthemostprominent.Otherriskfactorsincludekneemalalignment,
6、increasedbiomechanicalloadingofjoints,Osteoarthritisisthemostcommondegenerativejointincreasedbonedensity,andgenetics[8].disorder,affectingmorethanone-thirdofadultsaged65andolder[1-3].OArepresentsalargeandincreasingpublicDependingonthestudy,theprevalenceofradiographichealthburdenduetorisingratesofth
7、eagingpopulationandkneeOAinAmericansubjects45yearsofageandolderofobesity[4].Themostcommonlyaffectedperipheraljointsvariesbetween19.2%and27.8%,withwomenmorepredis-aretheknees,hipsandsmallhandjoints.OAcanbedi
