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1、ForewordThosewhodonotwanttoimitateanything,producenothing.—SalvadorDaliThereexistsacloseanalogybetweenthetrialsandtribulationsofachemistandthoseofanartisan.Justasanartistmustbalancethesensitiveinterplayofcolor,light,andbrushstroketocreateatimelesspainting,sotoomustthec
2、hemistcarefullymarshalthereagents,solvents,andreactionsthatoccupychemicalspacetosuccessfullyforgeanewmolecularentity.Findingreliable,standardizedproceduresforthoseroutinetransformationsisoftenatime-consumingandtediousprocess,onethatsubtractsfromeffortthatcouldbedevoted
3、towardsmorecreativeandexcitingpursuits.Indeed,muchoftheexcitement,fascination,andallureofsyntheticorganicchemistryresidesintheimaginativeexplorationofnewrealmsinchemicalreactivityandcomplexity,notthesearchforstandardoperationprocedures.InModernOrganicSynthesisintheLabo
4、ratory,Drs.JieJackLi,ChrisLimberakis,andDerekPflumprovideproceduresforthecommontransformationsandprotocolsthatpermeatethetapestryofsyntheticorganicchemistry.Fromguidelinesofproperflashchromatographytechnique,toproceduresfordryingsolvents,andrecipesforstainingsolutions,al
5、lofthebasic,yetessential,organiclaboratorytechniquesaredescribedindetail.Nearlyalltypesofcommonreactionsforoxidations,reductions,functionalgroupmanipulations,andC–Cbondformationarecovered.Withlittlequestion,thisbookisbeautifullysuitedforpractitionersofthefieldatalllevel
6、sofstudybecauseofthethoroughselectionofproceduresandalayoutthatisbothwelldesignedandcomprehensive.ContentsForewordviiAbbreviationsandAcronymsxv1FundamentalTechniques31.1Safety!31.2UsefulPreparations51.3Chromatography171.4Crystallization221.5ResidualSolventPeaksinNuclea
7、rMagneticResonance242FunctionalGroupManipulations282.1AlcoholOxidationState282.2KetoneOxidationState392.3AcidOxidationState443Oxidation553.1AlcoholtoKetoneOxidationState553.2AlcoholtoAcidOxidationState683.3OlefintoDiol703.4AldehydetoAcidOxidationState763.5HeteroatomOxid
8、ations78AbbreviationsandAcronymspolymersupportBINALHLithium2,2´-dihydroxy-Acacetyl1,1´-binaphthylethoxy-acacacetylace