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1、WWW.POLYMERPHYSICS.ORGPERSPECTIVETheoreticalPerspectiveonPropertiesofDNA-FunctionalizedSurfacesAbhishekSingh,HamedEksiri,YaroslavaG.Yingling911PartnersWay,DepartmentofMaterialsScienceandEngineering,NorthCarolinaStateUniversity,Raleigh,NorthCarolina27695Correspondenceto:Y.G.Yingling(E-mail:yara_yi
2、ngling@ncsu.edu)Received30June2011;revised7August2011;accepted8August2011;publishedonline31August2011DOI:10.1002/polb.22349ABSTRACT:ThemolecularrecognitionpropertiesofDNAgavematerials.ThisperspectivediscussestheunderstandingofrisetomanynovelmaterialsandapplicationssuchasDNAstructureanddynamicsofD
3、NAimmobilizedonthesurfacesbiosensors,DNA-functionalizedcolloidalmaterials,DNAori-fromthetheoreticalpointofviewincludingrecentprogressingamiandDNA-baseddirectedsurfaceassembly.TheDNA-analyticaltheories,atomisticsimulations,andcoarse-grainedfunctionalizedsurfacesareusedinbiosensorsandforpro-models.
4、VC2011WileyPeriodicals,Inc.JPolymSciPartB:grammedself-assemblyofbiological,organicandinorganicPolymPhys49:1563–1568,2011moietiesintonovelmaterials.However,surfacedensity,length,andlinkerdesignofthesurfacefunctionalizedDNAssignifi-KEYWORDS:DNA-functionalizedsurface;modeling;nanotech-cantlyinfluenc
5、ethepropertiesofDNA-drivenassembliesandnology;simulations;theoryINTRODUCTIONDNA,themoleculeresponsibleforstoragefunctionalizedwithDNAareprimarilyusedinbiosensingofgeneticinformationinthecell,hasbeengainingalotofdevices,whichtypicallyhaveadensecoverageofthiolatedattentioninbiotechnologyandnanotech
6、nologyduetoitsin-ssDNAs.DNA-functionalizedsurfacesarealsousedtodriveherentmolecularrecognitionability.Fromamaterialssci-theself-assemblyofbiological,organic,andinorganicmoi-enceperspective,DNAisaprogrammablepolymerwhoseetieswithnanometerresolution,whereDNAconstructsandphysico-chemicalpropertiesde
7、pendonitsnucleotidetheirsurfacecoveragecanvaryfromapplicationtoapplica-1,4sequence.DNAmoleculeisastringoffourtypesofnucleo-tion[Fig.1(a–e)].ThedesignofthesurfaceDNAcon-sides:adenine(A),guanine(G),thymine(T),andcytosine
