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To exploit the tumor microenvironment. Passive and active tumor targeting of

To exploit the tumor microenvironment. Passive and active tumor targeting of

ID：40984265

大小：1.23 MB

页数：12页

时间：2019-08-12

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1、JournalofControlledRelease148(2010)135–146ContentslistsavailableatScienceDirectJournalofControlledReleasejournalhomepage:www.elsevier.com/locate/jconrelReviewToexploitthetumormicroenvironment:Passiveandactivetumortargetingofnanocarriersforanti-cancerdrugdeliver

2、yaba,⁎FabienneDanhier,OlivierFeron,VéroniquePréataUniversitéCatholiquedeLouvain,LouvainDrugResearchInstitute,UnitofPharmaceutics,UCL-FARG7320,AvenueE.Mounier,B-1200,Brussels,BelgiumbUniversitéCatholiquedeLouvain,PoleofPharmacologyandTherapeutics,InstituteofExpe

3、rimentalandClinicalResearch,UCL-FATH5349,AvenueE.Mounier,B-1200,Brussels,BelgiumarticleinfoabstractArticlehistory:Becauseoftheparticularcharacteristicsofthetumormicroenvironmentandtumorangiogenesis,itisReceived31May2010possibletodesigndrugdeliverysystemsthatspe

4、cificallytargetanti-cancerdrugstotumors.MostoftheAccepted10August2010conventionalchemotherapeuticagentshavepoorpharmacokineticsprofilesandaredistributednon-Availableonline24August2010specificallyinthebodyleadingtosystemictoxicityassociatedwithserioussideeffects.Th

5、erefore,thedevelopmentofdrugdeliverysystemsabletotargetthetumorsiteisbecomingarealchallengethatisKeywords:currentlyaddressed.NanomedicinecanreachtumorpassivelythroughtheleakyvasculaturesurroundingActivetargetingPassivetargetingthetumorsbytheEnhancedPermeability

6、andRetentioneffectwhereasligandsgraftedatthesurfaceofEnhancedPermeabilityandRetentioneffectnanocarriersallowactivetargetingbybindingtothereceptorsoverexpressedbycancercellsorangiogenicNanocarriersendothelialcells.Thisreviewisdividedintotwoparts:thefirstonedescri

7、besthetumormicroenvironmentandthesecondonefocusesontheexploitationandtheunderstandingofthesecharacteristicstodesignnewdrugdeliverysystemstargetingthetumor.Deliveryofconventionalchemotherapeuticanti-cancerdrugsismainlydiscussed.©2010ElsevierB.V.Allrightsreserved

8、.Contents1.Introduction..............................................................1352.Tumormicroenvironment.......................................................1362.1.

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