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1、PharmaR&DAnnualReview201111ayisthetimewhenCitelineDrugIntelligence’sAnnualReviewoftrendsinpharmaceuticalR&DisMtraditionallyconducted.Itisausefulopportunitytopauseandreflectonhowtheindustryiscontinu-ingtoevolve,andisalsothetimewhenwetaketheannualsnapshotofourd
2、atawhichprovidesanewtimepointforourTrendsdatamoduleinoneofourdatabaseproducts,Pharmaprojects.Inthisarticle,weexaminethedatafor2011,lookathowithaschangedsince2010,andtrytoputtheinformationintosomesortofcontext.Someofthekeypointscoveredinthisreportinclude:•Grow
3、thofoverallR&Dpipelineflat•Fewnovelnewactivesubstanceslaunchedinpastyear•13%growthindrugsatPhaseIIIstatus•Pfizerholdspositionascompanywithmostdrugsindevelopment•Cancertakes28%sliceofR&Dpie•Pooryearfornewly-identifieddrugtargetsOverallDeclineinTOTalnumberOfacT
4、iveDrugsThetotalnumberofActivedrugscurrentlyreportedontheSoshouldwebeconcernedatallaboutthisapparenttaperingdatabaseisalmostunchangedfor2011,withthefigureofoff?InayearwhichhasseenmoreR&Djoblossesand9,713representingasmallbutinsignificantdecline(0.2%)faltering
5、recoveryinmanyoftheworld’seconomies,itisfromthe2010numberof9,737.Thiswouldappeartocon-probablyacomfortingsignthatthenumberofdrugsinfirmatrend,thebeginningsofwhichwereseenlastyear,developmenthasmore-or-lessheldup.Asweshallseeofaplateauingoffthelonger-termtrend
6、ofyear-on-yearwhenwecometodissecttheR&Dlandscapemoreclosely,increases.Figure1includesthetotalsreportedatthistimetherearesomeencouragingsignsregardingthequality,ifeachyearforeveryyearsince2001,andclearlyshowsthatnotthequantity,ofthedevelopmentpipeline.Butbefor
7、ethetrendformostofthepastdecadewasofslowannualmovingtothis,let’stakealookatthesuccessstoriesofgrowth(thestepincreasefrom2007-2008canbeattrib-2010–thenewactivesubstanceswhichmadetheirmarketutedtothebringingtogetherofdrugdatafromouroriginaldebutduringtheyear.da
8、tabasewiththatfromthethennewly-acquiredCitelinedatabaseofclinicaltrials,TrialTrove).Thosewhofollowthisfiguremorecloselyduringthecourseoftheyearmayhavefigure1:Totalsizeofthepipeline2001-20
