MGMT表达与非小细胞肺癌化疗疗效和预后关系的研究

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1、B3中国肺僥杂志2UU3年2刀第6卷弟1期ChinJl.ungOinwr.Flbrunry2UU3.'oL6・No.IMGMT表达与非小细胞肺癌化疗疗效和预后关系的研究吕金芳刘茹李彬邱雪杉李庆昌王恩华【摘要】目的研究MGMT在非小细胞肺癌INSC'LO组织中的表达悄况及其lJNSCLC#化疗疗效和预后的关系。方法应用免疫组化SF法检测正常肺组织及肿瘤组织中的MGMT喪达。将128例7SCI.C组织分为Mcr组（MGMT表达阴性）和Mer"组（MGMT表达阳性儿结果128例NS

2、6「128）・而10例正常肺纽织中未见MGMT表达。MGMT表达与肺癌患者性别.年龄、肿瘤分期、淋巴结转移、组织类型等临床生理病理特征均无明显关系.Mer组术肩平均生存期及生存率均较Mer'组明显延长（PV0.01・P<0.05）.45例可评价疗效的病例中・Mcr组总的化疗有效率为12.86%（921）.Mer'组为4.17%（1/24》（P<0.（）01）；Mcr组生存期和生存率明显高于Mer，组tP<0.01・P

3、指标。【关键词】非小细胞肺癌MGMT化疗【中图分类号】R73.3MGMTexpressionanditsrelationshipwithefficacyofchemotherapyandprognosisinpatientswithnon-smallcelllungcancerlAJJinJcuig*•LIURu•I」Bin•QIUXueshun9LIQin^chan^・WANGEnhua・*Departmeritof(^icologyMedicine•Anshunthe4thHospital.Anshun.

4、Liaoning114033•P.R.China.(Abstract]ObjectiveTostudytheexpressionofMGMTanditsrelationshipwithefficacyofchemotherapyandprognosisinpatientswithnon-smallcelllungcancer(NSC'IA)・MethodsMGMIwasdetectedin128MSCLl、tissuesand10normalpulmonarytissuesbyimnHinohistochc

5、mistry.AccordingtothelevelofMCjMT.128patientswithNSC'Ll'weredividedintothegroupMerwiihnegativeMGMTexpressionandthegroupMerwithpositiveMGMTexpression.ResultsMCiMTpositivelyexpressedin61of128patientswithNSC'IA'(47.66>zo)•hutnoneofnormalgroup.Nosignificantrela

6、tionshipwasfoundamongM(；MTexpressn沁nandTNMstages,lymphnodemetastasisandhistologicalclassificationofthecancer.However,(hemeansurvivalperiodsandsurvivalratesingroupMerweresignificantlyhigherthanthoseofgroupMer"(PV0.01•P<0.05).In45evaluablepatients^totalrespon

7、seraleswere42.Sb%andI.17%inMerandMer"patientsrcspvctively(P<0.001):andtherewereremarkablylongermeansurvivalperiodsandhighersurvivalratesinMerpatientsthanthoseinMer"patients(P<0.01•P

8、pyandprognosisinpatientswithNSt'LC.[Keywords]NSCLCMGMTChemotherapyThisworkwassupportedbyagrantfromtheScientificFundofAn?*hanScienceCommittee•LiaoningProvinceofChinaItoLUJinfang)(No.2001283).肿瘤细胞耐药是部分患者