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1、全身骨显像诊断肺癌骨转移临床价值［摘要］目的：探讨全身骨显像在诊断肺癌骨转移的临床价值，以便更好地指导肺癌患者的分期及治疗。方法：126例病理确诊为肺癌的患者均行全身骨显像、CT及碱性磷酸酶、血钙检查。统计肺癌患者不同病理类型、不同临床分期发生骨转移的几率，将全身骨显像与可疑骨转移临床因素(包括骨痛、碱性磷酸酶升高、高钙血症中任意一项或几项)诊断骨转移的准确性进行统计学比较。结果：肺癌骨转移的发生率为27.8%,周围型肺癌较中央型肺癌骨转移发生率高(P<0.01),肺腺癌较肺鳞癌骨转移发生率高(PV0.01),III、IV期患者骨转移发生率明显高于I、II期的患者(P<0.01)o全身骨显像诊
2、断肺癌骨转移的灵敏度(94.3%)、特异性(84.6%)、准确性(87.3%)均高于可疑骨转移临床因素对骨转移的诊断。结论：肺癌患者应常规行全身骨显像，这对肺癌的分期、治疗有着重要的临床意义。［关键词］肺癌；全身骨显像；骨转移［中图分类号］R734.2［文献标识码］B［文章编号］1673-7210(2011)11(c)-103-03ClinicalvalueofthewholebodyboneimagingindiagnosingbonemetastasisfromlungcancerJIALil,XIAZhengwu2,MAShixingl1.DepartmentofNuclearMedic
3、ine,YunnanProvincalCancerHospital,YunnanProvince,Kunming650118,China；2.DepartmentofLaboratory,KunmingGeneralHospitalofPLA,YurinanProvince,Kunming650032,China[Abstract]Objective：Toexploreclinicalvalueofthewholebodyboneimagingindiagnosingbonemetastasisfromlungcancer,inordertoguidestagingandtreatmentof
4、patientswithlungcancer.Methods：126patientswithpathologicaldiagnosisoflungcancerwereperformedwholebodyboneimaging,CTandALP,bloodcalciuminspection.Probabilityofbonemetastasisfromlungcancerofthedifferentpathologicaltypeanddifferentclinicalstagewerecounted.Thewholebodyboneimagingandclinicalfactorsofsusp
5、iciousbonemetastasis(includingbonepain,alkalinephosphatase,highcalciumlevels,arbitraryorafew)fordiagnosisaccuracyofbonemetastaseswerestatisticalcompared.Results：Theincidenceofbonemetastasisfromlungcancerwas27.8%,andthebonemetastasesoccurrenceprobabilityofperipherallungcancerwashigherthancentrallungc
6、ancer(P<0.01),bonemetastasesoccurrenceprobabilityoflungadenocarcinomawashigherthanlungsquamouscellcarcinoma(P<0.01),bonemetastasesoccurrenceprobabilityofperiodIII,IVpatientswasobviouslyhigherthanthatofperiodI,II(P<0.01).Thesensitivity(94.3%),specificdegrees(84.6%),accuracy(87・3%)ofthewholebodyboneim
7、agingdiagnosisofbonemetastasesfromlungcancerwerehigherthantheclinicalfactorsofsuspiciousbonemetastasisdiagnosisofbonemetastases・Conclusion：Wholebodyboneimagingshouldbearoutineexaminationinpatientswith
