病理学--心脑血管疾病1

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1、DiseaseofCardiovascularSystem舒细记刘丽江departmentofpathologyAtherosclerosisCoronaryatherosclerosis,coronaryheartdiseaseHypertensionRheumatismInfectiveendocarditisCardiacvalaveCardiomyopathy(myocardiopathy)MyocarditisProductiondepartmentofpathology概述疾病谱—发病率死亡率高疾病死因—第一位1985年城市冠心病标准

2、化死亡率43.7/10万,接近法国；农村20.5/10万,接近日本,仍低于发达国家。大多数心血管病—多基因异常departmentofpathologyAtherosclerosis(AS,ATH)departmentofpathologydepartmentofpathologyAmusculararteryfromayoungchilddepartmentofpathologyArteryfroma70-year-oldmandepartmentofpathologyATHischaracterizedbyintimallesionscall

3、edatheromas,oratheromatousorfibrofattyplaques,thatprotrudeintoandobstructvascularlumina,weakentheunderlyingmedia.departmentofpathologyATHprimaryaffectselasticarteriesandlargeandmedium-sizemusculararteries.departmentofpathologySubtypes:AtherosclerosisArteriolosclerosisMedialca

4、lcificationdepartmentofpathologySubtypes:AtherosclerosisArteriolosclerosisMedialcalcificationdepartmentofpathologyRiskfactor1.Hyperlipidemia2.Hypertension3.Cigarettesmoking4.Diabetes5.Familialpredisposition6.OtherfactorsdepartmentofpathologyRiskfactor1.Hyperlipidemia2.Hyperte

5、nsion3.Cigarettesmoking4.Diabetes5.Familialpredisposition6.OtherfactorsdepartmentofpathologyLDLVLDLHDLAS(ATH)departmentofpathologyThewell-establishedfamilialpredispositiontoATHandIHDismostlikelypolygenic.(IHD,ischemicheartdisease)departmentofpathologyRiskfactor1.Hyperlipid

6、emia2.Hypertension3.Cigarettesmoking4.Diabetes5.Familialpredisposition6.OtherfactorsdepartmentofpathologyHyperlipidemiaHypertensionDiabetesdepartmentofpathologyRiskfactor1.Hyperlipidemia2.Hypertension3.Cigarettesmoking4.Diabetes5.Familialpredisposition6.Otherfactorsdepartment

7、ofpathologyCigarettesmokingisawell-establishriskfactorinmenandisthoughttoaccountfortherelativelyrecentincreaseintheincidenceandseverityofATHinwomen.departmentofpathologyRiskfactor1.Hyperlipidemia2.Hypertension3.Cigarettesmoking4.Diabetes5.Familialpredisposition6.Otherfactorsd

8、epartmentofpathologydepartmentofpathologydepartmentofpathologydepart