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1、1DivisionofUrologicPathology,1Astheseentitieshavevaryingclinical:HierarchicalclusteranalysisisaneffectiveDistinctionofthesetumours,specifically31,2comprisedamixtureofPRCCandCRCCwithnoexpressionofC-kitorCK7andvariableS100A1andvimentin.PRCCwithstrongexpressionofC
2、K7clus-teredintogroupD.ApanelofS100A1(positive)andfocalCK7expressiondistinguishedROfromChRCCwith91%sensitivityand93%specificity.Apanelofvimentin(negative)andC-kit(positive)distinguishedROfromCRCCwith83%sensitivityand86%specificityandROfromPRCCwith79%sensitivitya
3、nd88%specificity.Conclusionsapproachtoanalysehigh-volumeimmunohistochem-icaldatatogenerateanoptimalpanelinthedifferentialdiagnosisofoncocytomafromitsmimics.carcinoma(ChRCC)andpapillary(PRCC)andclearcell(CRCC)renalcellcarcinomawitheosinophiliccyto-plasm.differen
4、tiationofbenignoncocytomafromothertumourswithmalignantpotentialiscritical.Duetoincreasingutilizationofimagingtechniques,anincreasingnumberofsmallindeterminatetumoursarebeingdiscoveredradiologicallyandbiopsiedpercu-taneously.DG&ShahRBhybridization;PPV,positivep
5、redictivevalue;PRCC,papillaryrenalinsitu16917958,169179.DOI:10.1111/j.1365-2559.2011.03753.x:Clusteranalysiswasperformedon58,oncocyticcytoplasmincludesoncocytoma2011,Histopathology:Todevelopanimmunohistochemicalstrategyfor2011BlackwellPublishingLimited.Histopa
6、thologyClusteranalysisofimmunohistochemicalprofilesdelineatesCK7,vimentin,S100A1andC-kit(CD117)asanoptimalpanelinthedifferentialdiagnosisofrenaloncocytomafromitsmimicsJasonCCarvalho,MatthewJWasco,LakshmiPKunju,DafyddGThomas&RajalBShahDepartmentofPathology,Unive
7、rsityofMichiganMedicalCenter,AnnArbor,MI,andCarisLifeSciencesandtheCarisResearchInstitute,Irving,TX,USADateofsubmission4February2010Acceptedforpublication20April2010CarvalhoJC,WascoMJ,KunjuLP,Thomas(2011)ClusteranalysisofimmunohistochemicalprofilesdelineatesCK7
8、,vimentin,S100A1andC-kit(CD117)asanoptimalpanelinthedifferentialdiagnosisofrenaloncocytomafromitsmimicsAimsdistinguishingrenaloncocytoma(RO)fromtheeosin-ophilicvariantofchromophobe
