10篇英文文献摘要学习

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1、ABSTRACT01:Parent-mediatedsocialcommunicationtherapyforyoungchildrenwithautism(PACT):long-termfollow-upofarandomisedcontrolledtrial.01、针对自闭症幼儿的父母介导的社区沟通疗法（PACT）：随机对照试验的长期随访杂志（THELANCET）发表年份（2016）期刊影响因子（53.254）Background:Itisnotknownwhetherearlyinterventioncanimprovelong-termautism

2、symptomoutcomes.Weaimedtofollow-upthePreschoolAutismCommunicationTrial(PACT),toinvestigatewhetherthePACTinterventionhadalong-termeffectonautismsymptomsandcontinuedeffectsonparentandchildsocialinteraction.Methods:PACTwasarandomisedcontrolledtrialofaparent-mediatedsocialcommunicatio

3、ninterventionforchildrenaged2–4yearswithcoreautism.Follow-upascertainmentwasdoneatthreespecialisedclinicalservicescentresintheUK(London,Manchester,andNewcastle)atamedianof5.75years(IQR5.42–5.92)fromtheoriginaltrialendpoint.Themainblindedoutcomeswerethecomparativeseverityscore(CSS)

4、fromtheAutismDiagnosticObservationSchedule(ADOS)自闭症诊断观察量表,theDyadicCommunicationAssessmentMeasure(DCMA)oftheproportionofchildinitiatiationswheninteractingwiththeparent,andanexpressive-receptivelanguagecomposite.Allanalysesfollowedtheintention-to-treatprinciple.Findings:121(80%)oft

5、he152trialparticipants(59[77%]of77assignedtoPACTinterventionvs62[83%]of75assignedtotreatmentasusual)weretracedandconsentedtobeassessedbetweenJuly,2013,andSeptember,2014.Meanageatfollow-upwas10.5years(SD0.8).Groupdifferenceinfavourof赞同thePACTinterventionbasedonADOSCSSoflog-oddseffe

6、ctsize(ES)was0.64(95%CI0·07to1·20)attreatmentendpointandES0.70(95%CI−0.05to1.47)atfollow-up,givinganoverallreductioninsymptomseverityoverthecourseofthewholetrialandfollow-upperiod(ES0.55,95%CI0.14to0.91,p=0.004).GroupdifferenceinDCMAchildinitiationsatfollow-upshowedaCohen'sdESof0.

7、29(95%CI−0.02to0.57)andwassignificantoverthecourseofthestudy(ES0.33,95%CI0.11to0.57,p=0.004).Therewerenogroupdifferencesinthelanguagecompositeatfollow-up(ES0.15,95%CI−0.23to0.53).Interpretation:Theresultsarethefirsttoshowlong-termsymptomreductionafterarandomisedcontrolledtrialofea

8、rlyinterventioninautismspectrumdi