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1、泛昔洛韦治疗带状疱疹的II期临床试验屮国临床药理学杂志2000年第3期第16卷论著作者：林宝珠曾凡钦毛越苹卞宗沛徐款珍郑岳臣曾敬思单位：林宝珠曾凡钦毛越苹卞宗沛(中山医科大学孙逸仙纪念医院皮狀科，广州，510120)；徐慧珍(上海第二医科大学瑞金医院皮肤科，上海，200025)；郑岳臣曾敬思(武汉同济保科大学协和医院皮肤科，武汉，430022)关键词：泛昔洛韦；帯状疱疹；临床试验摘要木临床研究釆用多中心、随机、对照试验，评价泛昔洛韦治疗带状疱疹的疗效和安全性，以阿昔洛韦作对照。泛昔洛韦治疗131例，阿昔洛韦治疗129例，共260例。研究结果为泛昔洛韦的止疱时间是2.82±I
2、.76d,阿昔洛韦是4.01±2.48d；两组结痂时间分别是5.12±2.84d和6.06±2.74d；脱痂吋间是11.48±3.87d和13.29±3.65d；疼痛缓解时间是4.31±2.47d和6.67±4.33d；急性神经痛消除时间是9.15±3.94d和12.19±4.25d；疱疹后神经痛的发生，泛昔洛韦是44/131(33.59%),阿昔洛韦是26/129(5&91%)。经统计学处理,两组间有显著性差异(P
3、和6.98%(P>0.05),两药对血液系统,肝、肾功能均无明显的影响。所有的临床资料证明，泛昔洛韦治疗带状疱疹疗效高，II耐受性好。PhaseIIClinicalTrialofFamciclovirinTreatmentofHerpesZosterLINBao-Zhu,ZENGFan-Qin,MAOYue-Ping(DepartmentofDermatology,SunYat-SenMemorialHospital,SunYat-SenUniversityofMedicalSciences,Guangzhou,510120)BIANZong-Pei,SUHu
4、i-Zhen(DepartmentofDermatology,RuiJinHospital,ShangHaiSecondUniversityofMedicalSciences,ShangHai,200025)ZHENGYue-Chen,ZENGJing-Si(DepartmentofDermatology,XieHeHospital,TongJiUniversityofMedicalSciences,WuHan,430022)AbstrastThisstudyconductedrandomizedcontrolled-multicenterclinicaltrail,toe
5、valuatetheefficacyandsaftyoffamciclovirinthetreatmentofherpeszoste匚Acyclovirwasclosenasthecontrol.Therewere131casesinfamciclovirgroupand129casesinacyclovirgroup,total260cases・Theresults:thetimestostopvesiculationwere2.82±1.76(d)forpatientsreceivingfamciclovirand4.01±2.48(d)forpatientreceiv
6、ingacyclovir.Thetimestofullcrustingoffamciclovirandacyclovirwere5.12±2.84(d)and6.06±2.74(d),thetimestolosscrustswere11.48+3.89(d)and13.29+3.65(d)respectively.Thetimestoreliefacute-phasepainwere4.31+2.47(d)offamciclovirvs.6.67+4.33(d)ofacyclovir.Thetimestoresolutionofacute-phasepainoffamcic
7、lovirwere9.15+3.94(d)vs.12.19+4.25(d)ofacyclovir.Ofthe131famciclovirgroup,44(33.59%)developedposteherpeticneuralgia,ofthe129acyclovirgroup,76(58.91%).Therewasstatisticalsignificantdifferencebetweenthetwogroups(P<0.01)・Theadversereactionsofthetwogroupswe
