联合检测CA125、CA19-9及AFP在卵巢癌临床诊断中的意义

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1、联合检测CA125、CA19-9及AFP在卵巢癌临床诊断中的意义联合检测CA125、CA19-9及AFP在卵巢癌临床诊断中的意义【摘要】目的：探讨联合检测血清癌抗原(CA125)、糖链抗原(CA19-9)及甲胎蛋白(AFP)的含量在临床诊断、疗效观察及病情检测的意义。方法：检测卵巢癌患者52例、卵巢良性肿瘤患者68例及健康妇女59例的血清样品，用化学发光法检测其血清CA125、CA19-9及AFP含量。结果：卵巢癌患者的CA125、CA19-9及AFP含量明显高于卵巢良性肿瘤和健康妇女组(P〈0・

2、01)；在早期卵巢癌患者中，CA125、CA19-9及AFP联合检测的阳性率较单独检测CA125高(P<0.05)；卵巢癌患者治疗前与治疗后血清CA125、CA19-9及AFP含量差异有显著性(P<0.05)o结论:联合检测血清CA125、CA19-9及AFP对卵巢肿瘤的良恶性辅助诊断及鉴别诊断具有一定的应用价值，尤其可以提高早期卵巢癌的阳性率。同时对卵巢癌的疗效观察和术后监测也具有重要价值。【关键词】卵巢癌；CA125；CA19-9；AFP文章编号:1009-5519(2007)12-1757-

3、02中图分类号:R73文献标识码：AClinicalsignificaneeofcombineddetectionofCA125>CA19-9andAFPinthediagnosisofovarycancerXINGAi-wen,GAOHong-jing(TheCentralHospitalofXinwenMiningIndustryGroup,Shandong271233,China)[Abstract]Objective：Tostudytheclinicalsignificanceofcomb

4、ineddetectionoftheserumcontentsofbloodserumsugarchainantigen(CA125)>Sugarchainantigen(CA19-9)andarmorembryoprotein(AFP)inthediagnosisofovarycancerandtheobservationofthecurativeeffect・Methods：TheserumcontentsofCA125>CA19-9andAFPin52patientswithovarycan

5、cer>68patientswithbenignovarytumorand59healthywomenweremeasuredbyautomaticchemiluminesceneeassay.Results：ThecontentsofCA125>CAI9-9andAFPinovarycancergroupweresignificantlyhigherthanthoseinbenignovarytumorandhealthywomengroups(P<0.01);Inearlystageofova

6、riancancer,thepositiveratesofcombineddetectionofCA125>CA19-9andAFPwerehigherthanthoseofCA125monomialdetection(P〈0.05)；ThecontentsofCA125>CA19-9andAFPinpatientswithovarycancerweresignificantlydifferentaftertreatment(P<0.05)・Conclusion：Theserumcontentso

7、fCA125、CAI9-9andAFPhaveacertainapplicationvalueinbenignormaligantassistancediagnosisanddifferentialdignosisofovarycancer,especially,mayenhancethepositiverateofearlyovariancancer；Combineddetectionofthreekindsofserumtumorsignsisvaluabletoobservethecurat

8、iverateandpostoperativemonitoroftheovarycancer・[Keywords]Ovarycancer；CA125；CA19❷9；AFP我们对卵巢肿瘤患者血清癌抗原(CA125)、糖链抗原(CA19-9)及甲胎蛋口(AFP)的联合检测，探讨对卵巢癌的诊断价值。1资料和方法1.1检测对象：本院妇科住院卵巢肿瘤患者120例。经临床和(或)病理确诊为卵巢癌52例，年龄16〜68岁，平均48.9岁。按国际抗癌联盟(UICC)分类进行临床TNM分期[2],将