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1、糖耐量减低患者胰岛素抵抗与血脂变化的临床观察［摘要］目的探讨糖耐量减低(IGT)患者胰岛素抵抗和血脂的相关性。方法选择2011年1月〜2013年1月来本院下属5家社康就诊的120例IGT患者作为实验组，选収同时期120例糖耐量正常志愿者作为对照组,分别测定两组入选者空腹胰岛素(Fins)水平、餐后2h胰岛索(2hlns)水平、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C).低密度脂蛋白胆固醇(LDL-C)、游离脂肪酸(FFA)等各项指标水平,并计算两组入选者胰岛素抵抗指数(H0MA-IR)、胰岛素分泌指数(HOMA-B)以及葡萄糖处置指数(GDI)
2、等。结果实验组TG、FFA、空腹血糖均显著高于对照组，IIDL-C明显低于对照组，差异均有统计学意义(P0.05)；实验组H0MATR、FIns^2hIns水平显著高于对照组，GDI显著低于对照组,差异均冇统计学意义(P〈0・05)。结论IGT患者有明显的胰岛素抵抗以及高血脂症状，因此临床中要注意防止出现高脂血症。［关键词］糖耐量减低；胰岛素抵抗；血脂［中图分类号］R587［文献标识码］B［文章编号］1674-4721(2013)11(c)-0187-02Clinicalobservationofinsulinresistanceandbloodlipidchanges
3、inpatientswithimpairedglucosetoleranceCHENYong-qingDepartmentofGeneralPractice,PeoplezsHospitalofYantianDistrictinShenzhenCityinGuangdongProvince,Shenzhen518081,China[Abstract]ObjectiveToexplorethecorrelationbetweeninsulinresistanceandbloodlipidinpatientswithimpairedglucosetolerance(IGT)
4、・Methods120patientswithIGTtreatedin5communityhealthservicecentersaffiliatedtoourhospitalfromJanuary2011toJanuary2013wereselectedasexperimentalgroup.Another120volunteerswithnornialglucosetoleranceinthesameperiodwerechosenascontrolgroup.Theindexeslikefastinginsulin(FTns)level,2hpostprandia
5、linsulin(2hIns)level,triglyceride(TG),totalcholesterol(TO),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL-C)andfreefattyacid(FFA)weretestedinbothgroupsinordertocalculatethehomeostasismodelassessmentofinsulinresistanee(HOMA-TR),homeostasismodelassessmentofBc
6、ellsecretion(HOMA-P)andglucosedisposalindex(GDI)•ResultsThelevelsofTG,FFA,andfastingblood-glucoseintheexperimentolgroupwereremarkablyhigherthanthoseofthecontrolgroup,whilethevalueofHDL-Cwasobviouslylowerthanthatofthecontrolgroupwithstatisticaldifferences(P0.05).ThelevelsofHOMA-IR,Finsand
7、2hInsintheexperimentalgroupwereobservablyhigherthanthoseofthecontrolgroup,buttheGDIwaslowerthanthatofthecontrolgroup,thedifferenceswerestatisticallysignificant（P〈O.05）・ConclusionDuetoobviousinsulinresistanceandhyperlipidemiainpatientswithIGT,thepreventionofitsoccurrencesh
