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1、马来酸罗格列酮治疗2型糖尿病临床观察【关键词】2型糖尿病【摘要】目的探讨喙哩烷二酮类胰岛素增敏剂马来酸罗格列酮(文迪雅)治疗2型糖尿病的临床疗效。方法将97例口服磺腺类降糖药血糖控制不满意的2型糖尿病患者随机分为两组，对照组加服盐酸二甲双M250mgtid治疗，治疗组加服文迪雅4mgqd治疗，疗程均为12周，将两组疗效进行比较。结果两组治疗后与治疗前比较FBG、2hBG、HbAlC、FINS、IRI、TG均显著降低(P<0.05),而治疗组与对照组比较经治疗后上述指标均明显降低，HDL-C增高(P<0.05),差异有显著性，且用文迪雅治疗无严重副作用。结论文迪雅对2型糖尿病患者有明显改善
2、脈岛素抵抗、降低血糖及调节脂代谢异常等作用，是治疗2型糖尿病有效和安全的口服降糖药物。【关键词】2型糖尿病；马来酸罗格列酮(文迪雅)ClinicalobservationofeffectofRosiglitazone(Avandia)intreatingtype2diabetesmellitusLIQing,GONGXi~li,LIUYu-jin.DepartmentofEndocrinology,XiangdongHospital,HunanNormal马来酸罗格列酮治疗2型糖尿病临床观察【关键词】2型糖尿病【摘要】目的探讨喙哩烷二酮类胰岛素增敏剂马来酸罗格列酮(文迪雅)治疗2型糖尿病
3、的临床疗效。方法将97例口服磺腺类降糖药血糖控制不满意的2型糖尿病患者随机分为两组，对照组加服盐酸二甲双M250mgtid治疗，治疗组加服文迪雅4mgqd治疗，疗程均为12周，将两组疗效进行比较。结果两组治疗后与治疗前比较FBG、2hBG、HbAlC、FINS、IRI、TG均显著降低(P<0.05),而治疗组与对照组比较经治疗后上述指标均明显降低，HDL-C增高(P<0.05),差异有显著性，且用文迪雅治疗无严重副作用。结论文迪雅对2型糖尿病患者有明显改善脈岛素抵抗、降低血糖及调节脂代谢异常等作用，是治疗2型糖尿病有效和安全的口服降糖药物。【关键词】2型糖尿病；马来酸罗格列酮(文迪雅)C
4、linicalobservationofeffectofRosiglitazone(Avandia)intreatingtype2diabetesmellitusLIQing,GONGXi~li,LIUYu-jin.DepartmentofEndocrinology,XiangdongHospital,HunanNormalUniversity,Liling412200,China[Abstract]ObjectiveToobservetheclinicaleffectofintreatingtype2diabetesmellitus.Methods97casesoftype2diabe
5、tesmellituspatientswithoralmonotherapyofsulphonylueaandbadbloodglucosecontrolwereselected・Theywererandomlydividedintotwogroups,oneofthemwasassignedtoreceiveadvandiafor12weeks,butanotherreceivedmetforminfor12weeks・Andtheclinicaleffectofthetwogroupswerecomparedintreatingtype2diabetesmellitus.Result
6、sBothtwogroupswereobservedsignificantlyreductioninfostingbloodglucose(FBG),2hourpostprandialblood-glucose(2hBG),meanglycosylatedhemoglobinA1Cvalues(HbAlC),fastingplasmainsulin(FINS),insulinresistanceindex(IRI)andserumtriglyceride(TG).ThelevelsofFBG,2hBG,HbAlC,FINS,IRI,TGweresignificantlydecreased
7、andserumHDL-Cwasincreasedinthegroupreceivedadvandiathanthegroupreceivedmetformin(P<0.05),Thediffeneewasobviousbetweenthetwogroups・Thesideeffectwasnotobserved.ConclusionRosiglitazone(avandia)iseffectiveindecreasingthele
