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1、利巴韦林注射液外用治疗手足口病皮疹疗效观察doi：10.3969/j.issn.1007-614x.2014.10.41摘要目的：观察利巴韦林注射液治疗手足口病皮疹消退的疗效。方法：将65例手足口病患儿随机分为治疗组35例和对照组30例，两组均按普通型手足口病患儿给予退热、补液、口服阿昔洛韦、加强手卫生护理等对症治疗。治疗组患儿给予利巴韦林注射液，取适量直接涂敷皮疹处，3〜4次/日，连用3〜5天；对照组给予炉廿石洗剂外涂皮疹，3〜4次/日，连用3~5天。评价两组治疗效果，比较两组皮疹消退时间、住院时
2、间、体温恢复正常时间的差异。结果：治疗组总有效率（97.14%）优于对照组总有效率（90.00%）,差异有统计学意义（P0.05）o结论：采用利巴韦林注射液外涂手足口病，患儿皮疹消退时间缩短，方法简单，显效快，无不良反应，是临床治疗手足口病安全可靠的选择。关键词利巴韦林注射液手足口病皮疹临床观察CurativeeffectobservationofribavirininjectioninthetreatmentofrashofhandfootandmouthdiseaseFanXiaoyangDep
3、artmentof卩ediatries,theMaternalandChi1dHea1thHospitalofGuigangCity,GuangxiZhuangAutonomousRegion530000AbstractObjective：ToexploretheeffectofribavirininjectioninthetreatmentofrashofHandfootandmouthdisease.Methods：65patientswithhandfootandmouthdiseasewer
4、erandomlydividedintothetreatmentgroupwith35casesandthecontrolgroupwith30cases.Thetwogroupsweregivensymptomatictreatment,suchasabatementoffever,fluidinfusion,oralacyclovir,strengthenthehandsofhealthcareandsoon.Thetreatmentgroupweregivenribavirininjectio
5、nwhichwasdirectlycoatedrashwithrightamount,3〜4times/day,usedfor3~5dayscontinu.Thecontrolgroupwasgivencalaminelotioncoatedwithaskinrash3~4times/day.usedfor3〜5dayscontinu.Weevaluatedthetherapeuticeffectsoftwogroups,comparedtheskinrashsubsideddifferencesi
6、ntime,hospitalizationtimeandbodytemperaturereturnedtonormaltimeoftwogroups.Results：Thetotalefficiencyofthetreatmentgroup(97・14%)washigherthan(90%)incontrolgroup,thedifferencewasstatisticallysignificant(卩0.05).Conclusion：Thehandfootandmouthdiseasewascoa
7、tedwithribavirininjectionfortreatment,theskinrashsubsidedtimeofchildrenisshortened,themethodissimple,anditseffectiveisquickandnoadversereaction,soitisasafeandreliablechoicefortheclinicaltreatmentofhandfootandmouthdisease.KeywordsRibavirinTnjection；Hand
8、footandmouthdisease；Rash；Clinicalobservation手足口病是由肠道病毒引起的儿童传染病，临床表现以手、足和口腔黏膜疱疹或破溃示形成溃疡为主，个别重症患儿病情发展快可导致死亡,好发于5岁以下儿童［1］。治疗手足口病普通型的文献相关研究结果表明,采用利巴韦林注射液的临床治疗效果与采用传统炉甘石洗剂临床治疗效果存在不同程度的差异［2〜6］。为了进一步研究和比较临床治疗手足口病普通型采用利巴韦林注射液外用治疗方法的优势，为手足口病普通型的
