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1、®CONCISEREVIEWSOFPEDIATRICINFECTIOUSDISEASESCONTENTSCoronaviruses:FromCommonColdstoSevereAcuteRespiratorySyndromeControversiesinPalivizumabEDITORIALBOARDCo-Editors:RobertS.Baltimore,MDandStanfordT.Shulman,MDEditorsforthisIssue:ToniDarville,MD,andEllenChadwick,MDBoardMembersMic
2、haelCappello,MDLaurenceB.Givner,MDKatherineO’Brien,MD,MPHEllenG.Chadwick,MDCharlesT.Leach,MDJosephW.St.Geme,III,MDToniDarville,MDKathleenAnneMcGann,MDJohnR.Schreiber,MD,MPHFrancisGigliotti,MDH.CodyMeissner,MDJeffreyR.Starke,MDCoronavirusesFromCommonColdstoSevereAcuteRespirator
3、ySyndromeSusanC.Baker,PhDKeyWords:coronaviruses,severeacute3Province,mainlandChina.InFebruaryandsufficientforcausationofSARS.respiratorysyndrome,SARS2003,atleast9individualsatahotelinWhethercofactorssuchascoinfection,HongKonglikelycameintocontactenvironmentalorgeneticfactorsen-
4、(PediatrInfectDisJ2004;23:10491050)withamanfromGuangdongwiththehancetheseverityortransmissibilityof2atypicalpneumonia.Afterthe9returnedthediseaseremainsunclear.CoronaviruseswerefirstidentifiedinthehomefromHongKong,thediseasespread1960s,causingrespiratoryandentericdis-toSingapore
5、,Vietnam,Canadaandelse-easesinhumansanddomesticanimals(Table1).HumancoronavirusesOC43where.Dr.CarloUrbani,aphysicianinTHESOURCEOFSARSand229Ecauseone-thirdofcommonVietnamwhosubsequentlydiedaftercon-InitialreportsfromVietnam,coldseachwinter.1Thenamecoronavirustractingtheatypical
6、pneumonia,wasoneHongKongandTorontosuggestedthatreflectstheelectronmicroscopic(EM)ap-ofthefirsttoalerttheWorldHealthOr-SARSwasapreviouslyundescribedse-ganization(WHO)tothenewillness.Onverepneumonia.2Wheredidthisdiseasepearanceofviralparticlesstuddedwithspikeglycoproteinsthatproje
7、ctoutlikeaMarch12,2003,WHOissuedaglobalcomefrom?Analysisofserafrompa-2crownoracorona.1Whenvirusparti-alertforthenewdiseaseSARS.Interna-tientsandcontrolsindicatedthatSARS-clesfrompatientswithsevereacuterespi-tionalcooperationledtorapididentifica-CoVhadnotbeenendemicinhumansrator
8、ysyndrome(SARS)in2003weretionofanovelcoronavirusasthecaus-bef
