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1、雌激素受体、孕激素受体在甲状腺乳头状癌中表达及临床意义［摘要］目的探讨雌激素受体（ER孕激素受体（PR）在甲状腺乳头状癌、甲状腺腺瘤中表达情况。方法用SABC免疫组化法检测ER、PR在164例甲状腺乳头状癌、128例甲状腺腺瘤、40例正常甲状腺组织中表达情况，并分析ER、PR的表达与甲状腺乳头状癌患者性别、淋巴转移的相关性。结果ER、PR在甲状腺乳头状癌、甲状腺腺瘤中表达阳性率明显高于正常组织，其差异具有高度统计学意义（x2=40.01,33.47,P<0.01；x2=8.19,8.40,P<
2、0.01）,甲状腺乳头状癌和甲状腺腺瘤ER、PR阳性表达差异具有高度统计学意义（X2=24.56、16&,P<0.01甲状腺乳头状癌患者中淋巴转移者、无淋巴结转移者的ER、PR阳性表达差异具有高度统计学意义（x2=18.39、8.84,P<0.01结论ER、PR参与甲状腺乳头状癌的发生、发展，检测ER、PR能对甲状腺乳头状癌的早期诊断和预后提供帮助。［关键词］雌激素受体；孕激素受体；甲状腺乳头状癌［中图分类号］R736.1［文献标识码］A［文章编号］1673-7210(2012)07(b)-
3、0019-02ExpressionandclinicalsignificanceofestrogenreceptorandprogesteronereceptorinpapillarythyroidcarcinomaGUOHaipenglPENGYuhui2LIUMuyuanlYANGXihonglADepartmentofHeadandNeckSurgery,theHospitalAffiliatedtoShantouUniversityMedicalCollege,GuangdongProv
4、ince,Shantou515031,China;2.DepartmentofLaboratory,theHospitalAffiliatedtoShantouUniversityMedicalCollege,GuangdongProvince,Shantou515031,China[Abstract]ObjectiveToevaluatetheexpressionandclinicalsignificanceofestrogenreceptor(ER)andprogesteronerecept
5、or(PR)inpapillarythyroidcarcinomaandthyroidadenom・MethodsImmunohistochemistry(SABC)wasusedtodetecttheexpressionofER,PRin164casesofpapillarythyroidcarcinoma,128casesofthyroidadenoma,40casesofnormalthyroidtissue・Thecorrelationbetweenexpressionandclinic
6、alfeaturesincludinghistologicaltype,genderdisparityandlymphaticmetastasiswereanalyzed・ResultsComparedwiththenormalthyroidtissue,thepositiveratesofERandPRwerehigherinpapillarythyroidcarcinomaandthyroidadenoma,withstatisticalsignificance(x2=40.01,33.47
7、,P<0.01;x2=8.19,8.40,P<0.01).TherewassignificantdifferenceofER,PRexpressionsbetweenpapillarythyroidcarcinomaandthyroidadenoma(x2=24.56,16.81,P<0.01).TherewassignificantdifferenceofER,PRexpressionsbetweenlymphaticmetastasisandwithoutlymphaticmetastasi
8、sofpapillarythyroidcarcinoma.(x2=18.39,8.84,P<0.01).ConclusionERandPRbothcontributetothedevelopmentofpapillarythyroidcarcinoma.[Keywords]ER;PR;Papillarythyroidcarcinoma甲状腺肿瘤是头颈部最常发肿瘤，以甲状腺乳头状癌为最常见的甲状腺恶性肿瘤病理类型。女性发病率大于男性，以育龄期中青年女性为常见发病人群。近年研究发现，非性激素靶器官也
