血清亲环素 A与急性动脉粥样硬化性脑梗死关系研究.pdf

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1、淮海医药》2014年5月第32卷第3期JHuaihaiMed，May2014，Vo1．32，No．3血清亲环素A与急性动脉粥样硬化性脑梗死关系研究王茂林，汪恩焕，周钟阳，马骥，王宏伟，张妮娜【摘要】目的联合检测急性动脉粥样硬化性脑梗死患者血清亲环素A(CyPA)、基质金属蛋白酶一9(MMP-9)和高敏c反应蛋白(hs．CRP)表达，探讨三者在急性动脉粥样硬化性脑梗死中的作用。方法观察组为急性动脉粥样硬化性脑梗死患者60例，选取我院同期体检证实为健康者60例为对照组。采用ELISA法检测2组患者血清中CyPA及MMP-9浓度，采用乳胶免疫比浊法检测2组

2、血清中hs-CRP浓度，进行统计学分析。结果观察组血清中CyPA、MMP．9和hsCRP浓度明显高于对照组(P<0．001)。观察组患者血清中CyPA与MMP-9浓度呈正相关(r=0．64，P<0．001)；观察组患者血清中CyPA与hs．CRP浓度呈正相关(r=0．71，P<0．001)；观察组患者血清中MMP-9与hs—CRP浓度呈正相关(r=0．61，P<0．001)。结论急性脑梗死患者血清CyPA、MMP一9和hs-CRP浓度显著升高，其可能与患者动脉粥样硬化斑块稳定性相关。【关键词】急性脑梗死；动脉粥样硬化；亲环素A；基质金属蛋白酶一9；高

3、敏c反应蛋白【中图分类号】R541．4【文献标识码】A【文章编号】1008-7044(2014)03-0221-02RelationofcyclophilinAandacuteatherothromboticcerebralinfarctionWANGMao-Z，WANGEn—huan，ZHOUZhong-yang，eta1．(DepartmentofNeurosurgery，BengbuThirdPeople'sHospital，Anhui233000，China)【Abstract】ObjectiveToexploretheroleofcyclo

4、philinA(CyPA)，matrixmetalloproteinase-9(MMP-9)andhighsensi-tiveC．reactiveprotein(hs—CRP)inpatientswithacuteatherothromboticcerebralinfarction．Methods60patientswithacuteatherothromboticcerebralinfarctiontreatedinourhospitalwereselectedasanobservationgroup．Meanwhile，another60peop

5、leconfirmedtobehealthybyphysicalexaminationwereselectedasacontrolgroup．TheserumlevelsofCyPAandMMP一9weremeasuredbyELISA。andtheserumlevelofhs．CRPwasmeasuredbyimmunecolorimetricmethod．ResultsTheserumCyPA，MMP一9andhs—CRPconcentrationintheobservationgroupweresignificantlyhigherthanth

6、oseinthecontrolgroup(P<0．001)．SerumCyPAwascorrelatedpositivelywithserumMMP一9andhs—CRPinthepatientswithacuteatherothromboticcer-ebralinfarction(r1=0．64，r2=0．71，P<0．001，P<0．001，respectively)．SerumMMP-9wascorrelatedpositivelywithserumhs-CRPinpatientswithacuteatherothromboticcerebr

7、alinfarction(r3=0．61，P<0．001)，butnotpeopleinthecontrolgroup．ConclusionTheincreaseofserumCyPA，MMP一9andhs—CRPlevelsmightbesignificantlycorrelatedwiththestabilityofca—rotidplaques．【Keywords】Acutecerebralinfarction；Atherosclerosis；CyclophilinA；Matrixmetalloproteinase一9；Highsensitiv

8、eC—reac一急性脑梗死(ACI)的发病率、复发率及致死率高，临床危脉血3ml，分离血清，置于一80％冰箱