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1、多囊卵巢综合症患者不同促排卵方案临床疗效分析【摘要】目的：以行体外受精-胚胎移植(IVF-ET)治疗的多囊卵巢综合症(卩COS)患者为研究对象，分别采用GnRH激动剂(GnRH-a)长方案(I组)、GnRH拮抗剂(GnRH-A)方案(II组)进行促排卵治疗,通过两组临床结局的比较，寻求更适宜PCOS患者的促排卵治疗方案。方法：选择2008年1月至2010年6月就诊于我院不孕不育专科门诊的62名多囊卵巢综合症患者，这些患者在我院门诊接受促排卵治疗后于北京大学人民医院生殖中心接受TVF-ET治疗。根据不同的促排卵方案
2、将患者分成两组，比较各组患者的基本特征、Gn用药天数、Gn量、HCGRLH水平、E2水平、获卵数、受精率、妊娠率、周期取消率、OIISS发生率等。结果：两组患者Gn剂量差异有统计学意义(P0.05)；两组患者的HCGH血清E2水平、LII水平差异有统计学意义(P0.05)o结论：使用GnRH-A方案有效减少了TVF-ET的PCOS患者Gn的使用量，减轻了患者的经济和心理负担，是PCOS患者行VF-ET较为适宜的促排卵方案。【关键词】多囊卵巢综合症；GnRH激动剂；GnRH拮抗剂；体外受精-胚胎移植Curative
3、effectofdifferentovulationSimulationschemeforpatientswithpolycysticovarysyndromeWUXiangchun.DepartmentofObstelricsandGynecology,QinhuangdaoHarborHospital,Qinhuangdao066000,China【Abstract]Objectives：Patientswithpolycysticovarysyndrome(PCOS)andhavingreceivedinv
4、itrofertilization一embryotransfer(IVF-ET)treatmentwereregardedastheresearchobject.2schemes,GnRHagonist(GnRH-a)longscheme(groupI)andGnRHantagonists(GnRH-A)scheme(groupII)wereadoptedtostimulateovulation,toidentifytheovulationsimulationschememoresuitableforpatien
5、tswithPCOSthroughcomparingtheclinicaloutcomesofthetwogroups.Methods:Sixty-twopatientswithpolycysticovarysyndromecametotheDepartmentofTnfertilityofourhospitalbetweenJanuary2008andJune2008wereselected・Afterreceivingovulationsimulationtreatmentinourhospital,the6
6、2patientswenttothereproductivecenterofPekingUniversityPeople'sHospitaltoreceiveIVF-ETtreatment・Accordingtothedifferentovulationstimu1ationschemeadopted,patientsweredividedinto2groups・Thebasiccharacteristics,numberofdaystakingGn,amountofGn,levelofLIIandE2onIIC
7、Gdays,numberofeggs,fertilizationrate,pregnancyrate,cyclecancellationrateandtheincidenceofOHSSandetcofthetwogroupswerecompared.ResuIts：TheamountofGnintheGnRH-Agroupwas1owerthanGnRH-alongscheme,demonstratingsignificantstatisticaldifference(P0.05)；thelevelsofser
8、umE2andLIIonIICGdaywereofsignificantstatisticaldifference(卩0.05)•Conclusion：GnRH-AschemeeffectivelyreducestheusageofGnforpatientswithPCOSandIVF-ETtreatment,thuslyreducingtheeconomicandpsy
