冠状病毒Coronavirusl论文-1983 [Advances in Virus Research] Volume 28 __ The Molecular Biology of Coronaviruses.pdf

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1、ADVANCESINVIRUSRESEARCH,VOL28THEMOLECULARBIOLOGYOFCORONAVIRUSESLawrenceS.SturmanCenterforLaboratoriesandReseorch,NewYorkStateDepartmentofHealthAlbany,NewYorkKathrynV.HolmesDeportmentofPathology,UniformedServicesUniversityoftheHealthSciencesBethesda,Maryland................

2、.................3636B.EmergenceofCoronaviruses..............................3739394143D.ViralGenome.......,............54E.ViralLipids.........................................56F.OtherHost-DerivedComponents................................5758111.ViralReplication..........

3、........................................60A.Summary..........................._....._._......60B.Adsorption,Penetration,andUncoa60C.CharacterizationofViralmRNAs...............................63D.KineticsofIntracellularSynthesis,Processing,andTransport68......,..........74F

4、.VirionAssembly,Release,andCytopathicEffects................79838585IV.StructureandBiologicalActivitiesofCoronavirusGlycoproteins......87A.ThePeplomericGlycoprotein,E2...............................81B.TheMatrixGlycoprotein,El...................................92V.Antigeni

5、cRelationshipsamongCoronaviruses94VI.Conclusions.........................................95References,.......9835CopyrightD1983byAcademicPress,IncAllrightsofreproductionInanyformreservedISBN0-12-039828-136LAWRENCES.STURMANANDKATHRYNV.HOLMESTheimageofprogressinscienceasakin

6、dofconquestofanunknowndomainwithadefinite“frontier”andsuccessive‘breakthroughs’seemstomemoreandmoretobeonlyaromanticillusion....Therearemanyfrontiersanditcomesdowntothefactthatinscienceonecanonlysometimestalkofprogress.Wheneverthereisanad-vance,thereisafrontier,nottheother

7、wayaround.GeorgeE.Uhlenbeck(1971,p.449-450)’Factsarenevercompletelyindependentofeachother...everyfactreactsuponmanyothers.Everychangeandeverydiscoveryhasaneffectonaterrainthatisvirtuallylimitless.Itischaracteristicofadvancedknowledge,maturedintoaco-herentsystem,thateachnew

8、factharmoniously-thougheversoslightly-changesallearlierfacts.Hereeverydiscoveryisactually