冠状病毒Coronavirusl论文-1993 Induction of protective immunity against coronavirus-induced encephalomyelitis_ Evidence for an important role of C.pdf

冠状病毒Coronavirusl论文-1993 Induction of protective immunity against coronavirus-induced encephalomyelitis_ Evidence for an important role of C.pdf

ID:51817659

大小:763.64 KB

页数:5页

时间:2020-03-16

冠状病毒Coronavirusl论文-1993 Induction of protective immunity against coronavirus-induced encephalomyelitis_ Evidence for an important role of C.pdf_第1页
冠状病毒Coronavirusl论文-1993 Induction of protective immunity against coronavirus-induced encephalomyelitis_ Evidence for an important role of C.pdf_第2页
冠状病毒Coronavirusl论文-1993 Induction of protective immunity against coronavirus-induced encephalomyelitis_ Evidence for an important role of C.pdf_第3页
冠状病毒Coronavirusl论文-1993 Induction of protective immunity against coronavirus-induced encephalomyelitis_ Evidence for an important role of C.pdf_第4页
冠状病毒Coronavirusl论文-1993 Induction of protective immunity against coronavirus-induced encephalomyelitis_ Evidence for an important role of C.pdf_第5页
资源描述:

《冠状病毒Coronavirusl论文-1993 Induction of protective immunity against coronavirus-induced encephalomyelitis_ Evidence for an important role of C.pdf》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库

1、Eur.J.Immunol.1993.23:1757-1761Coronavirusprotein-specificprotectiveimmuneresponseinrats1757EgbertFlory,InductionofprotectiveimmunityagainstMichaelPfleiderer.,AlbertStuhlerandcoronavirus-inducedencephalomyelitis:evidenceHelmutWegeforanimportantroleofCD8+Tcellsinvivo*InstituteofVir

2、ologyandImmunobiology,UniversityofCoronavirusMHV-JHMinfectionsofratsprovideusefulmodelstostudytheWurzburg,Wurzburgpathogenesisofvirus-inducedcentralnervoussystemdisease.ToanalyzetheroleoftheimmuneresponseagainstdefinedMHV-JHMantigens,wetestedtheprotectiveefficacyofvacciniavirus(VV

3、)recombinantsexpressingeitherthenucleocapsid(N)orthespike(S)protein.AstrongprotectionwasmediatedinanimalsbyimmunizationwithrecombinantVVencodingawild-typeSprotein(VV-Swildtype),whereasVVrecombinantexpressingamutantS354~~protein(VV-S354~~)hadnoprotectiveeffect.RecombinantVVencoding

4、Nprotein(VV-N)inducesahumoralandaCD4+Tcellresponse,butdidnotpreventacutediseaseregardlessoftheimmunizationprotocol.Intheseexperiments,challengewithanotherwiselethaldoseofMHV-JHMwasperformedpriortotheinductionofvirus-neutralizingantibodiesandstudieswiththeanti-CD8+monoclonalantibod

5、y,MRCOX8showedthateliminationoftheCD8+subsetofTcellsabrogatestheprotectiveeffect.ThisresultindicatesthatCD8+TcellsprimedbyrecombinantVVexpressingwild-typeSproteinareaprimarymechanismofimmunologicaldefenseagainstMHV-JHMinfectioninrats.1Introductiondiseaseinmiceandrats[8-111.Also,pr

6、otectiveneutraliz-ingantibodiescanbeinducedbyimmunizationofmicewithCoronavirusinfectionsofthecentralnervoussystem(CNS)purifiedSproteinoranSproteindecapeptide[12,131.areinterestingmodelstoanalyzemechanismsofinflamma-Theseresultsimpliedthatthehumoralimmuneresponsetorydemyelinationan

7、dviruspersistence.InparticularthemaybesufficientfortheobservedprotectionagainstmurinecoronavirusstrainMHV-JHMinducesdifferentMHV-JHMinfection.coursesofencephalomyelitisinmiceorrats[l,21.ATcell-mediatedimmunityisalsobelievedtobecrucialforInLewisrats,differentformsofthediseasehavebe

8、enthecontrolofcoronavirusinfectio

当前文档最多预览五页,下载文档查看全文

此文档下载收益归作者所有

当前文档最多预览五页,下载文档查看全文
温馨提示:
1. 部分包含数学公式或PPT动画的文件,查看预览时可能会显示错乱或异常,文件下载后无此问题,请放心下载。
2. 本文档由用户上传,版权归属用户,天天文库负责整理代发布。如果您对本文档版权有争议请及时联系客服。
3. 下载前请仔细阅读文档内容,确认文档内容符合您的需求后进行下载,若出现内容与标题不符可向本站投诉处理。
4. 下载文档时可能由于网络波动等原因无法下载或下载错误,付费完成后未能成功下载的用户请联系客服处理。