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1、CorrespondenceAIDS2004,18:829–835CoronavirusinfectioninanAIDSpatientA30-year-oldChinesemanpresentedinApril2003tosteroidwastailedoffover4weeks.HetoleratedtheapublichospitalinHongKongforsuspectedseveretreatmentandremainedasymptomaticuntilday25acuterespiratorysyndrome(SARS).H
2、ehadbeenwhenthefeverrelapsed(seeFig.1)andachestX-raylivingwithHIV(currentlyatstageCIII)for5yearsshowedincreasedrightlowerzonehaziness.Twoandwasonhighlyactiveantiretroviraltherapysputumsmearsforacid-fastbacilliwerepositive(taken(HAART)comprisingabacavir300mgtwiceaday,ondays
3、29and30).Hewasstartedonanti-tuberculosisefavirenz600mgatnight,Kaletra4capsules(eachtreatmentandhisfeversubsidedafteroneday.Thefirstcapsulecontainslopinavir133.3mgandritonavirantibodiestestforcoronavirusonadmissionwasnega-33.3mg)andtenofovir300mgtwiceaday,plustive,whereasthe
4、secondtitretaken2weeksafterthestandardPneumocystiscariniipneumoniaprophylaxis.Heonsetofsymptomswas1:40.CoronavirusPCRtestshadbeenonthepresentHAARTregimensincewererepeatedforthroatandnasalswabs,stoolandNovember2002andhadgooddrugadherence.Hisurineonday39andwerenegative.CD4ce
5、llcountandviralloadwere134cells/ìland470copies/ml[byreversetranscriptasepolymeraseThisisthefirstreportedcaseofSARSinanHIV-chainreaction(PCR),RocheAmplicor],respectively,infectedpatient.ThediagnosisofSARSwasmadeinFebruary2003.clinically,supportedbylymphopenia,positivePCRands
6、erologyforSARS-associatedcoronavirus.OurThepatientgaveaone-weekhistoryofright-sidedpatientranarelativelymildcoursedespitehisimmu-chestpainandchills,followedbyfever,increasingdrynocompromisedstate.Therearetwopossiblereasonscoughandmalaise.Onadmission,hehadafeverofforthisobs
7、ervation.First,theHAARTregimenmight388C,wasmildlytachypnoeic;andhisbloodpressurehaveprotectiveantiviraleffectsduringtheviraemicwas155/77mmHg,withapulserateof90/min.Thephase.Kaletrahasbeenfoundtohavesomein-vitropulseoximetryread97%whileonoxygen3l/min.activitiesagainstcorona
8、virus,andwasusedasanTherewasnoaddedsoundonchestexamination.experimentaltreatmentagentinso
