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Identificationofα-FodrinasanAutoantigeninExperimentalCoronavirusRetinopathy(ECOR)MarianS.Chin,LauraC.Hooper,JohnJ.Hooks,BarbaraDetrickPII:S0165-5728(14)00144-1DOI:doi:10.1016/j.jneuroim.2014.05.002Reference:JNI475906Toappearin:JournalofNeuroimmunologyReceiveddate:
2、1November2013Reviseddate:19March2014Accepteddate:4May2014Pleasecitethisarticleas:Chin,MarianS.,Hooper,LauraC.,Hooks,JohnJ.,Detrick,Barbara,Identificationofα-FodrinasanAutoantigeninExperimen-talCoronavirusRetinopathy(ECOR),JournalofNeuroimmunology(2014),doi:10.1016/j.jneuroim.2014
3、.05.002ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringthep
4、roductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.ACCEPTEDMANUSCRIPTIdentificationof-FodrinasanAutoantigeninExperimentalCoronavirusRetinopathy(ECOR)1112MarianS.Chin,LauraC.Hooper,JohnJ.HooksandBarbaraDetrick1Immuno
5、logyandVirologySection,LaboratoryofImmunology,NationalEyeInstitute,NationalInstitutesofHealth,Bethesda,MD2DepartmentofPathology,JohnsHopkinsUniversity,SchoolofMedicine,Baltimore,MDCorrespondingauthorACCEPTEDMANUSCRIPT:BarbaraDetrick,Ph.D.,Director,ImmunologyLaboratory,Department
6、ofPathology,JohnsHopkinsUniversity,SchoolofMedicine,B-125Meyer,600NWolfeSt,Baltimore,MD.M.Chin-p.1ACCEPTEDMANUSCRIPTAbstractThecoronavirus,mousehepatitisvirus(MHV),JHMstraininducesabiphasicdiseaseinBALB/cmicethatconsistsofanacuteretinitisfollowedbyprogressiontoachronicretinaldeg
7、enerationwithautoimmunereactivity.RetinaldegenerationresistantCD-1micedonotdevelopeitherthelatephaseorautoimmunereactivity.AmouseRPE/choroidDNAexpressionlibrarywasscreenedusingserafromvirusinfectedBALB/cmice.Twocloneswereidentified,villin-2proteinanda-fodrinprotein.A-fodrinprote
8、inwasusedforfurtheranalysisandwesternblotreacti
