analysis of dna sequences

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1、DNAsequenceanalysisGenepredictionmethodsGeneindicesMappingcDNAongenomicDNAGenome-genomecomparisonApplicationsComputationalMolecularBiologyMPIforMolecularGeneticsexon2exon1exonnpromotor5‘UTR3‘UTRProteincodingsequenceexonn-1DNAsequencesgenestructure(eucaryotes)Computationa

2、lMolecularBiologyMPIforMolecularGeneticsDNAsequencesrepeats,repetitiveelementsLongINterspersedElementsSINE(e.g.Alu)TransposonsSimplerepeats(e.g.ATATA...)ComputationalMolecularBiologyMPIforMolecularGeneticsDNAsequencesrepeats,repetitiveelementsHighcopynumberSequencevariab

3、ilityMostlylocatedinuntranslatedregionsComputationalMolecularBiologyMPIforMolecularGeneticsGenepredictionStrategiesfordetectingORFs/exonsDistributionofstopcodonsCodonusageHexamerfrequenciesPredictionofthecodingframeSplicesiterecognition(Eucaryotesonly)ComputationalMolecu

4、larBiologyMPIforMolecularGeneticsGenepredictionbysequencecomparisonComparisonofgenomicDNAandcDNA/ESTsComparisonofrelatedgenomicDNAofdifferentorganismsComputationalMolecularBiologyMPIforMolecularGeneticsGenepredictionCodonusage(singleexon)Frame1Frame2Frame3codingnon-codin

5、gComputationalMolecularBiologyMPIforMolecularGeneticsGenepredictionCodonusage(singleexon)Frame1Frame2Frame3codingnon-codingcorrectstartcodingsequenceComputationalMolecularBiologyMPIforMolecularGeneticsGenepredictionCodonusage(multipleexons)Frame1Frame2Frame3codingnon-cod

6、ingSplicesitesExons:208..2951029..13491500..16882686..29343326..34443573..36804135..43094708..48464993..50967301..73897860..80138124..84058553..87139089..922513841..14244ComputationalMolecularBiologyMPIforMolecularGeneticsGenepredictionCodonusage(multipleexons)Frame1Fram

7、e2Frame3codingnon-codingSplicesitesExons:208..2951029..13491500..16882686..29343326..34443573..36804135..43094708..48464993..50967301..73897860..80138124..84058553..87139089..922513841..14244ComputationalMolecularBiologyMPIforMolecularGeneticsGenepredictionAdditionalcrit

8、eriaDetectionofStartcodonsDetectionofpotentialpromotorelementsDetectionofrepetitivesequences(mostlyuntr