WHITESSENCE_菠萝蜜美白精华.pdf

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1、402483_Dep_4P_WHITESSENCE24/05/0714:14Page2WHITESSENCE™LighteningconcentrateDecreaseinmelanintransfertokeratinocytes:inhibitionofmelanosomephagocytosis.Lightening,unifyingandanti-darkspotaction:significantresultsonAsianskinafter2months.402483_Dep_4P_WHITESSENCE24/

2、05/0714:14Page3NangkaseedsWHITESSENCE™Nangkaorjackfruit(Artocarpusheterophyllus)isatypicalAsiantreeisastrongnaturalbelongingtoMoraceaefamily.AvailableinmarketsacrossIndia,lighteningagentThaïlandandIndonesia,itshugefruitsareappreciatedfortheirdeliciouspulpandcanbee

3、atenfreshorcooked.ThelargeseedsextractedfromAsiancontainahighlevelofuniqueproteinswhichhavebeenconcentratednangkaseeds.inWHITESSENCE™.ThespecificproteinsofWHITESSENCE™inhibitthetransferTargetingthemelaninofmelaninfromtransfertokeratinocytesmelanocytestokeratinocyt

4、es.ColorintheskinistheresultoftheproductionanddistributionofThedecreaseinmelaninintheepidermis.Melaninissynthesizedbymelanocytesthemelaninquantitywhicharedentriticcellslocatedinthebasallayeroftheepidermis.Pigmentsareproducedinspecializedvesiclescalledmelanosomes.a

5、tthesurfaceofThepigmentsaretransportedbythedentritesfortransfertothetheskinresultsinneighbouringkeratinocytesbyphagocytosis.Onceinsidetheaclearandunifiedkeratinocytes,themelaninisusedtocoatthecellnucleusgivingcolortotheskin.complexion.Nangkaproteinshaveahighcapaci

6、tytoinhibitmelanosomephagocytosis.ConcentratedinWHITESSENCE™,theyprovideasignificantlighteningeffect.Invitroevaluation%inhibition30TheabilityofWHITESSENCE™2525%**toinhibitphagocytosiswas20evaluatedinvitrousingfluorescentbeadstomimictheroleof1515%**melanosomes.Used

7、atverylow1012%*levels,WHITESSENCE™isanimportantinhibitorofthis5phenomenon(upto25%)0exhibitingadosedependanteffect.0,0066%0,0133%0,0533%WHITESSENCE™ConcentrationTestedonnormalnegroidhumanepidermalmelanocytes/keratinocytescocultures.Resultsareexpressedas%ofvariation

8、versusuntreatedcontrolafter24hoursofincubation*Statisticallysignificant(p<0.05).**Statisticallysignificant(p<0.01).WHITESSENCE™INHIBITSTHEPHAGOCYTOSISOF