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1、降钙素原在小儿重症感染细菌感染性疾病预后中指导意义研究［摘耍］目的探析降钙素原在小儿重症感染细菌感染性疾病中的应用及在疾病预后指导中的价值。方法以该院2010年6月一2013年10月期间所收治的108例重症感染细菌感染性疾病患儿作为研究对象，分为观察组和对照组。分别测定两组降钙素原水平与C反应蛋白水平，对照组结合C反应蛋白水平测定结果进行治疗，观察组结合降钙素原测定结果治疗,比较两种检测方法敏感性与特异性、住院时间及病死率。结果两组降钙素原、C反应蛋白测定结果的比较均差异无统计学意义(P>0.05),观察组住院时间为(8・2±2.1)d,病死率为0%
2、,明显比对照组的(13・4±3・0)d和5.7%(3/53)更小，组间对比差异有统计学意义(1X0.05)。两组降钙素原测定的敏感性、特异性与两组C反应蛋白所测定相比均更高，差异有统计学意义(卩〈0.05)。结论在重症感染细菌感染性疾病患儿的临床治疗中动态监测其血清降钙素原变化情况可有效反映患儿感染情况进而为临床治疗提供指导，对于改善疾病预后具有重要意义。［关键词］降钙素原；感染性疾病；细菌；预后［中图分类号］R44［文献标识码］A［文章编号］1674-0742(2015)02(b)-0058-03guidingsignificanceofProca
3、lcitonininchildrenwithsevereinfectionintheprognosisofbacterialinfectiondiseaseLIUYangThecenterhospitalofZhuMadianChildrensseveredivision,463000China[Abstract]ObjectiveToexploreguidingsignificanceofProcalcitonininchildrenwithsevereinfectionintheprognosisofbacterialinfectiondisea
4、se.MethodsSelect.108casesofsevereinfectionsufferedfrombacterialinfectiousdiseasesinchildreninourhospitalinJune2010-October2013asstudyobject,weredividedintotwogroups,measuredthetwogroupsofprocalcitoninandCreactiveproteinlevel,thecontrolgrouptreatwithserumCRPmeasurementresults,ob
5、servationgrouptreatwithprocalcitoninresults,comparisonofthesensitivityandspecificityoftwofordetectingmethod,timeofhospitalizationandmortalityrate>ResuItsTwogroupsofprocalcitoninandCreactiveproteinassayresultsshowednosignificantdifference(P>0.05),observationgrouphospitalizationt
6、ime(8.2+2.1)days,thefatalityratewas0%,significantlylowerthanthecontrolgroup(13.4+3.0)and5.7%(3/53),withsignificantdifference(P<0.05),therewasstatisticalsignificance.Thesensitivity,specificityandCreactiveproteinowasdeterminedoftwogroupswerecomparedhigher,differencewassignificant
7、(P<0.05),differenceswerestatisticallysignificant.ConclusionInclinicaltreatmentofdiseasesinchildrenwithbacterialinfectioninthedynamicmonitoringofserumprocalcitoninchangecanreflectthesituationofchildrenwithinfectiontoprovideguidanceforclinicaltreatmentofsevereinfectionand,hasimpo
8、rtantsignificanceforimprovingprognosisofthedisease・降钙索
