参附注射液应用于儿童支气管哮喘治疗的临床研究.doc

《参附注射液应用于儿童支气管哮喘治疗的临床研究.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、参附注射液应用于儿童支气管哮喘治疗的临床研究［摘要］目的观察参附注射液应用于儿童支气管哮喘治疗的临床效果。方法选择支气管哮喘患儿60例，随机分为对照组和参附组，每组30例。对照组应用吸氧、抗感染、糖皮质激素、解痉平喘常规治疗；参附组给予上述常规治疗的同时辅用参附注射液1.5mL/kg(1次/d)。评估临床控制效果，测定呼岀气冷凝液IL-4和IFN-Y浓度，并行血气分析。结果与对照组比较，参附组患儿肺氧合指标改善，呼出气冷凝液IL-4浓度和IL-4/IFN-y比值降低，IFN-丫浓度升高(P［关键词］哮喘；呼出气冷凝液；参附注射液［中图分类号］R272［文献标识码］B［文章编

2、号］1673-9701(2014)31-0070-03ClinicalstudyontheeffectsofShenfuinjectioninChildrenwithbronchialasthmaHUANGFujunlCHENXiudilZHUJinhui2l.DepartmentofPediatrics,ShangyuPeople'sHospitalinZhejiangProvince，Shangyu312300,China；2.DepartmentofAnesthesiology,YueqingPeople"sHospitalinZhejiangProvince，Yue

3、qing325600,China[Abstract]ObjectiveToinvestigatetheeffectsofShenfuinjectiononthetreatmentofChildrenwithbronchialasthma・MethodsSixtychildrendiagnosedasbronchialasthmawererandomlyallocatedintotwogroups：thecontrolgroupandShenfugroup,30casesineachgroup,respective!y.Thechildreninthecontrolgroup

4、receivedconventionaltherapyincludingoxygeninhalatiorbanti・infection,glucocorticoidandspasmolysis,whileadditionaldailyadministrationof1.5ml/kgShenfuinjectionwasgiveninShenfugroup・Afterseverrdaytreatment，clinicaleffectandarterialgasanalysiswereevaluated,andexhaledbreathcondensateswerecollect

5、ed；IL-4andIFN-ylevelsinexhaledbreathcondensatesweremeasuredusingELISAkits.ResultsAscomparedtocontrolgroup,thepulmonaryoxygenationofchildreninShenfugroupwereimproved,IL-4concentrationandIL-4/IFN-丫ratioinexhaledbreathcondensatesweredecreased,andIFN-丫levelwasenhanced(P0.05),见表2。表1两组患儿一般资料比较2.

6、2两组患儿呼出气冷凝液细胞因子浓度与治疗前比较，两组患儿治疗后呼出气冷凝液IL・4和IFN・Y浓度升高，而参附组呼出气冷凝液IL-4/IFN-y比值较治疗前降低，差异有统计学意义（P