脑动静脉畸形--大学课件.ppt

《脑动静脉畸形--大学课件.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、CEREBRALARTERIOVENOUSMALFORMATIONSAVM:aTLAfortheCNSIncidence0.52%atautopsySlightmalepreponderance(1.09to1.94)Congenitallesions(althoughrarelyfamilial)EmbryologyFirsthalfofthirdweekofgestationepiblasticcellsmigratetoformmesodermmesodermalcellsdifferentiat

2、etoarterialandvenousvesselsonthesurfaceoftheembryonicnervoussystemEmbryologyFirsthalfofthirdweekofgestationepiblasticcellsmigratetoformmesodermmesodermalcellsdifferentaitetoarterialandvenousvesselsonthesurfaceoftheembryonicnervoussystemSeventhgestational

3、weekvesselssproutbranches&penetratedevelopingbrainreachthegray-whiteinterface,eitherloopbacktopialsurfaceortraverseentireneuraltube,thusepicerebral&transcerebralcirc'neventuallyconnectarterialandvenoussystemsbyaroundthetwelfthweekPathology&Pathophysiolog

4、yabsenceofnormalcapillarysystemPathology&PathophysiologyabsenceofnormalcapillarysystemusualfunctiondisplacedPathology&PathophysiologyabsenceofnormalcapillarysystemusualfunctiondisplacedasymptomaticatbirthPathology&Pathophysiologyabsenceofnormalcapillarys

5、ystemusualfunctiondisplacedasymptomaticatbirthvesselschangewithtimemaydevelopaneurysmsparenchymalchangeswithinandaroundthelesionPathology&Pathophysiologyabsenceofnormalcapillarysystemusualfunctiondisplacedasymptomaticatbirthvesselschangewithtimemaydevelo

6、paneurysmsparenchymalchangeswithinandaroundthelesionsitefrequencyisproportionaltobrainvolumePathology&PathophysiologyabsenceofnormalcapillarysystemusualfunctiondisplacedasymptomaticatbirthvesselschangewithtimemaydevelopaneurysmsClinicalpresentation95%hav

7、esymptomsbyageof70yearsClinicalpresentation95%havesymptomsbyageof70yearspeakpresentationsecondtofourthdecadeClinicalpresentation95%havesymptomsbyageof70yearspeakpresentationsecondtofourthdecadehighoutputfailure,neonate,veinofGalenhydrocephalus,firstdecad

8、eheadache,hemorrhage,seizures,2nd&3rdClinicalpresentationfactorscontributingtosymptomsvesselwalls,flowandpressuresClinicalpresentationfactorscontributingtosymptomsvesselwalls,flowandpressuresenlargementandencroachmentClini