老年人冠心病与缺血性脑卒中载脂蛋白E基因多态性对比研究.pdf

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1、1610GuangxiMedwaZJournaf，Dec．2012，Vo1．34，No．12老年人冠心病与缺血性脑卒中载脂蛋白E基因多态性对比研究▲吕泽峰庞国防胡才友吕渊(1广东省惠州市第四人民医院内科，惠州市516055，E—mail：lvzf69@163．com；2广西壮族自治区江滨医院神经内3科，南宁市530021)【摘要】目的探讨老年人冠心病与缺血性脑卒中载脂蛋白E(ApoE)基因分布及其与临床类型的关系。方法>60岁的冠心病患者68例(急性心肌梗死38例、不稳定型心绞痛30例)和>60岁的缺血性脑卒中患者61例(脑梗死30例、短暂性脑缺血发作31例)，健康人156例为对照组，采

2、用PCR进行ApoE基因分型。结果3组ApoE基因型分布及等位基因频率比较，差异有统计学意义(P<0．05)；冠心痛组及缺血性脑卒中组各基因型及等位基因频率比较，差异无统计学意义(P>0．05)；正常对照组ApoEa3为优势基因，冠心病组及缺血性脑卒中组ApoEs,4基因频率及等位基因频率均较对照组高(P<0．05)；急性心肌梗死、不稳定型心绞痛、脑梗死、短暂性脑缺血发作4组ApoE~-,4基因阳性率比较，差异无统计学意义(P>0．05)。结论ApoEa4(+)是老年人冠心病与缺血性脑卒中共同危险因素，其机理可能与ApoEs4阳性促进动脉粥样硬化有关。【关键词】缺血性脑卒中；冠心病；载脂

3、蛋白E；基因多态性【中图分类号】R541．4；R743【文献标识码】A【文章编号】0253-4304(2012)12—1610-03ComparativeStudyonApofipoproteinEGenePolymorphismsbetweenCoronaryHeartDiseaseandlschemicStrokeintheElderlyLVZe~ng，PANGGuo乒。，HUCai-you，LVYuan(DepartmentofInternalMedicine，theFourthPeopleSHospitalofHuizhouCity，Huizhou516005，China；2De

4、partmentofNeurology，JiangbinHospital，GuangxiZhuangAutonomousRegion，Nanning530021，China)【Abstract】ObjectiveToexplorethedistributionofapolipoproteinE(ApoE)geneanditsclinicaltypesintheelderlywitllischemicstrokeorcoronaryheartdisease(CHD)．MethodsSixtyeightCHDpatientsaged60yearsandover(CHDgroup)includ

5、ing38casesofacutemyocardialinfarctionand30casesofunstableanginapectoris，andsixtyonepatientswithischemicstroke(IS)aged60yearsandover(ISgroup)including30ca$~sofcerebralinfarctionand31casesoftransientischemicattackwereenrolledinthestudy，156normalinthecontrolgroup．PCRwasappliedtoclassifyApoEgene．Resu

6、ltsThedistributionofApoEgeneandtheallelefrequencyshowedsignificantdiferenceamongthreegroups(P<0．05)，butdidnotshowedsignificantdiferencebetweenCHDgroupandISgroup(P>0．05)．ApoEs3wasthedominategeneinthecontrolgroup，thefrequenciesofApoE~4geneandallelewerehigherintheCHDgroupandISgroupthanthoseinthecont

7、rolgroup(P<0．05)．TherewasnosignificantdiferenceinpositiverateofApoE~4geneamongfourgroupsincludingpatientswitllacutemyocardialinfarction，unstableanginapectoris，cerebralinfarctionandtransientischemicattack(P>0．05)．Conclu