2、ectswithessentialhyper2显著预测因子。血浆BNP水平和左心耳血流速度呈tension[J].AmJHypertens,2004,17(5pt2):228A.[4]张素华.原发性高血压病伴房颤患者血浆ET和BNP的含量变化[J].放射显著负相关(r=0.38,P<0.05)。但是此项研究入选免疫学杂志,2006,23(3):78.病例数少,同时对于血栓组,BNP的测定在血栓形成[5]牛萍,黄从新,杨波,等.脑钠肽对心房颤动患者复律和复发的评价作用[J].中华心律失常杂志,2007,2(11):28.后,故
3、BNP对血栓形成的预测价值需要进一步的前瞻[6]VinchCS,RashkinJ,LogsettyG,etal.Brainnatriureticpeptidelevelsfallrapid2性研究证实。lyaftercardioversionofatrialfibrillationtosinusrhythm[J].Cardiology,2004,102:1882193.5BNP的应用前景[7]Wozakowska2KaplonB.Effectofsinusrhythmrestorationonplasmabrainnatri
4、2综上所述,房颤患者监测血BNP浓度在临床评ureticpeptideinpatientswithatrialfibrillation[J].AmJCardiol,2004,93:155521558.价、指导治疗和评估预后等方面有重要价值。已有多[8]JourdainP,BelloriniM,FunckF,etal.Short2termeffectsofsinusrhythmresto2个研究表明BNP在房颤时发生改变,更能反映房颤时rationinpatientswithloneatrialfibrillation:aho
5、rmonalstudy[J].EurJHeartFail,2002,4:2632267.血流动力学变化、复律后稳定性及血栓栓塞等并发症,[9]MabuchiN,TsutamotoT,MaedaK,etal.Plasmacardiacnatriureticpeptideasa揭示潜在器质性心脏病及心功能不全。在一定的临床biologicalmarkerofrecurrenceofatrialfibrillationinelderlypeople[J].NipponRonenIgakkaiZasshi,2000,37:53525
6、40.背景下作为一项生化指标,BNP测定具有价廉、检测[10]HorieH,TsutamotoT,MinaiK,etal.Brainnatriureticpeptidepredictschronic方便、可靠、重复性强等优点,相信随着相关研究的进atrialfibrillationafterventricularpacinginpatientswithsicksinussyndrome[J].JpnCircJ,2000,64:9652970.一步深入,BNP在包括房颤在内的心血管疾病中应用[11]TakahashiY,Yos
7、hitoI,TakahashiA,etal.AVnodalablationandpacemaker将更为广泛。implantationimproveshemodynamicfunctioninatrialfibrillation[J].PACE,2003,26:121221217.[12]马长生,周玉杰.北京地区非瓣膜病心房颤动患者缺血性脑卒中发生率及[参考文献]影响因素的随访研究[J].中华心血管病杂志,2002,30(3):1652167.[13]ShimizuH,MurakamiY,InoueS,etal.Highpl
8、asmabrainnatriureticpolypep2[1]EllinorPT,LowAF,PattonKK,etal.Discordantatrialnatriureticpeptideandtidelevelasamarkerofriskforthromboembolisminpat
