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1、REPORTSPemetrexeddisodium17.CloydJC,DuttaS,CaoGetal.Valproate20.DuttaS,ReedRC,ChunAHetal.Morn-22.Dataonfile.AbbottLaboratories,Abbottunboundfractionanddistributionvol-ingversuseveningdosingofdivalproexPark,IL;2004May.umefollowingrapidinfusionsinpatientsextended-releas
2、etabletsdoesnotmakea23.CloydJC,FischerJH,KrielRLetal.withepilepsy.EpilepsyRes.2003;53:19-27.difference:abiopharmaceuticandsafetyValproicacidpharmacokineticsin18.BeydounA,SackellaresJC,ShuV.Safetycomparison.Epilepsia.2003;44(supplchildren.IV.Effectsofageandantiepi-ande
3、fficacyofdivalproexsodiummono-9):96.Abstract.lepticdrugsonproteinbindingandin-therapyinpartialepilepsy:adouble-21.YukawaE,ToH,OhdoSetal.Popula-trinsicclearance.ClinPharmacolTher.blind,concentration-responsedesigntion-basedinvestigationofvalproic1993;53:22-9.clinicaltr
4、ial.Neurology.1997;48:182-8.acidrelativeclearanceusingnonlinear24.BourdetSV,GidalBE,AlldredgeBK.19.PeruccaE,DulacO,ShorvonSetal.Har-mixedeffectsmodeling:influenceofPharmacologicmanagementofepilepsynessingtheclinicalpotentialofantiepi-drug–druginteractionandpatientinth
5、eelderly.JAmPharmAssoc.2001;lepticdrugtherapy—dosageoptimiza-characteristics.JClinPharmacol.1997;41:421-36.tion.CNSDrugs.2001;15:609-21.37:1160-7.PhysicalcompatibilityofpemetrexeddisodiumwithotherdrugsduringsimulatedY-siteadministrationLAWRENCEA.TRISSEL,CHRISTOPHERA.S
6、AENZ,ABAYOMIB.OGUNDELE,ANDDELSHALONDAS.INGRAMemetrexeddisodiumisaninves-tigationalmultitargetedanti-Purpose.Thephysicalcompatibilityofdimeteratoneandfourhours.Allcombi-Ppemetrexeddisodiumwithselectedothernationswithoutvisualincompatibilityfolateantineoplasticagentbein
7、gdrugsduringsimulatedY-siteinjectionwaswereassessedwithaparticlesizer–evaluatedinclinicaltrialsforusestudied.counter.inthetreatmentofsolidtumors.1Methods.A5-mLsampleofpemetrexedResults.Ofthe79pemetrexed–secondaryPemetrexedisadministeredasanin-disodium20mg/mLin0.9%sodi
8、umchlo-drugcombinations,55werecompatiblefortravenousinfusionin0.9%sodiumrideinjectionwascombinedwith5mLofaatleastfourhours.H
