栀子豆豉陷胸汤合栀子厚朴汤治疗反流性食管炎60例的临床观察-论文.pdf

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1、·中医中药·2013年9月第20卷第26期栀子豆豉陷胸汤合栀子厚朴汤治疗反流性食管炎60例的临床观察薛心东青海省循化县人民医院中西结合内科．青海循化811100【摘要】目的观察栀子豆豉陷胸汤合栀子厚朴汤治疗反流性食管炎(RE)的临床效果及安全性。方法选择符合人选条件的RE患者116例，随机分为两组，治疗组60例，给予中药栀子豆豉陷胸汤合栀子厚朴汤治疗；对照组56例，给予奥美拉唑胶囊联合西沙必利片口服治疗，两组均以8周为1个疗程，比较两组1个疗程内的近期疗效及停药后半年的远期疗效。结果经1个疗程治疗后，治疗组在临床症状的改善及内

2、镜下食管黏膜的恢复方面与对照组的疗效相近(P>O．05)，且无明显不良反应，对肝肾功能无影响。停药后半年内治疗组的复发率明显低于对照组(P<0．05)，治疗组的远期疗效优于对照组。结论栀子豆豉陷胸汤合栀子厚朴汤治疗RE具有较好的疗效及安全性『关键词1反流性食管炎；栀子豆豉陷胸汤；栀子厚朴汤；临床疗效【中图分类号】R243【文献标识码】A【文章编号】1674—4721(2013)09(b)一0128—03TheclinicalobservationofZhizidouchixianxiongdecoctioncombinedwi

3、thZhizihoupodecoctionintreatmentofrefluxesophagitisin60casesXUEXin—dongDepartmentofInternalMedicineofIntegrationofTraditionalChineseandWesternMedicine，PeopleSHospitalofXunhuaCountyinQinghaiProvince，Xunhua8l1100，China[Abstract]ObjectiveToobservetheclinicaleffectandsa

4、fetyofZhizidouchixianxiongdecoctioncombinedwithZhizihoupodecoctionintreatmentofrefluxesophagitisfRE)．Methods116patientswithREmeetingtheselectioncriteriawererandomlydividedintothetwogroups．Inthetreatmentgroup(n=60)，theZhizidouchixianxiongdecoctioncombinedwithZhizihou

5、podecoctionwasprovided，whileinthecontrolgroup=56)，patientswereprescribedomepra—zolecapsulecombinedwithcisapridetabletfororaladministration．Onecourseoftreatmentlasted8weeksinbothgroups．Theshort—termeffectwithinonecourseoftreatmentandlong-termeffecthalfayearafterdrugd

6、iscontinuedinthetwogroupswerecompared．ResultsAfteronecourseoftreatment，theimprovementofclinicalmanifestationsandrecoveryofesophagealmueosaunderendoscopeinthetreatmentgroupwerealmostthesameastheydisplayedintheontrolgroupfP>0．05)andtherewaswasnoobviousadversereactiona

7、ndnoinfluenceonhepatorenalfunctioninthetreatmentgroup．TherecurrenceratehalfayearafterdrugdiscontinuedinthetreatmentgroupwasremarkablylowerthanthatinthecontrolgroupfP<0．05)．thelong—termeffectinthetreatmentgroupwassuperiortothatinthecontrolgroup．ConclusionZhizidouchix

8、ianxiongdecoctioncombinedwithZhizihoupodecoctioncanobtainagoodeffectandsafetyontreatingRE．[Keywords]Refluxesophagitis；Zhizidouchixianxiong