阿托伐他汀对急性脑梗死患者神经功能康复的作用及颈动脉内膜厚度的影响.pdf

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1、中国实用神经疾病杂志2014年7月第17卷第14期ChineseJournalofPracticalNervousDiseasesJu1．2014Vo1．17No14·9·阿托伐他汀对急性脑梗死患者神经功能康复的作用及颈动脉内膜厚度的影响胡冰凌四川巴中市中心医院神经内科巴中636000【摘要】目的研究阿托伐他汀(ATVT)对急性脑梗死(ACI)患者神经功能(NF)康复的作用以及颈动脉内膜中层厚度(IMT)的影响。方法将我院2010-08-2013-08入院就诊的122例ACI病患随机分成2组，对照组给予常规治疗，观察组在此基础上加用ATVT。观察2组患者治疗前后

2、神经功能缺损程度(Nervefunctiondamagedegree，NFDD)、IMT变化以及疗效。结果观察组治疗后NFDS评分、颈动脉IMT均显著小于治疗前及对照组治疗后，差异均具有统计学意义(均P<0．05)。观察组基本痊愈率、总有效率均显著高于对照组；观察组病死率显著低于对照组，差异均具有统计学意义(均P<0．05)。结论AVTV治疗ACI疗效显著，能有效促进患者NF康复，降低颈动脉IMT，值得临床推荐。【关键词】阿托伐他汀；急性脑梗死；神经功能；动脉内膜厚度【中图分类号】R743．33【文献标识码】A【文章编号】1673—5110(2014)14-00

3、09—03Effect0fatorvastatinonnervefunctionrehabilitatiOnandcarotidintimamediathicknessinpatientswitha-cutecerebralinfarctionH“BinglingDepartmentofNeurology，theCentralHospitalofBazhong，Bazhong636000，China[Abstract]0bjectiveTosudytheeffectofatorvastatinonnervefunctionrehabilitationandcar

4、otidintimamediathicknessinpatientswithacutecerebralinfarction．Methods122casesofpatientswithacutecerebralinfarctioninourhospitalfromAug2010toAug2013wererandomlydividedintotWOgroups．Thecontrolgroupwasgivenconventionaltreatment：theobservationgroupwasaddedwithatorvastatin．Thedegreeofnerv

5、efunctiondamage，carotidintimamediathickness(IMT)andtheeffec—tivenessoftwogroupsbeforeandaftertreatmentwerecompared．ResultsNFDSscore．carotidIMToftheobservationgroupaftertreatmentweresignificantlylessthanthosebeforetreatmentandthoseofthecontrolgroupaftertreatment，thediffer—encesweresta

6、tisticallysignificant(P<0．05)．Theobservationgroup'sbasicrecoveryrateandtotalefficiencywerehigherthanthoseofthecontrolgroup；theobservationgrou~smortalitywassignificantlylowerthanthatofthecontrolgroup，thediffer—enceswerestatisticallysignificant(P<0．05)．ConclusionAtorvastatinhasagoodeff

7、ectonpatientswithacutecerebralin-farction，whichcaneffectivelypromotetherehabilitationofpatientswithNF。reducetheIMTofcarotidartery．Itisworthyofrecommendingclinically．[Keywords]Atorvastatin；Nervefunctionrehabilitation；Carotidintimamediathickness；Acutecerebralinfarction；Effect随着近年人口老龄化的

8、加剧，脑血管疾病(cer