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《大鼠背根神经节植入碘125粒子治疗神经病理性痛：可微损伤节内细胞但不会影响后肢功能？.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、大鼠背根神经节植入碘125粒子治疗神经病理性痛：可微损伤节内细胞但不会影响后肢功能？碘125放射治疗可降低癌症患者的痛感。考虑到脊髓背根神经节在外周感觉传导中起着重耍作用，中国医学科学院放射医学研究所张腾达所在团队，设计了使用放射性粒子碘125植入大鼠L5背根神经节后降低神经病理性疼痛。结果证实，大鼠L5背根神经节植入碘125后可致疼痛的阈值升高，尽管会出现背根神经节细胞的微损伤，但并未影响后肢的运动功能。文章发表在《中国神经再生研究(英文版)》杂志2014年6月第12期。透射电镜下显示，大鼠L5背
2、根神经节植入29.6MBq的1251粒子后1,440h,大量背根神经节出现核膜皱缩，部分核膜模糊，内质网坏死。Article:"Implantingiodine・225seedsintoratdorsalrootganglionforneuropathicpain:neuronalmicrodamagewithoutimpactinghindlimbmotion,”byLingJiaol,TengdaZhangbWantingMa2,Huixin呂Wang2,WenyiZhangl,SaijunFa
3、nl,XiaodongHuo2,BaosenZheng2(1InstituteofRadiationMedicine,ChineseAcademyofMedicalScierices,Tianjin,China;2SecondAffiliatedHospitalofTianjinMedicalUniversity,Tianjin,China)JiaoL,ZhangTD,WangHX,ZhangNFanSJ,HuoXD,ZhengBS,MaWT.Implantingiodine・125seedsi
4、ntoratdorsalrootganglionforneuropathicpain:neuronalmicrodamagewithoutimpactinghindlimbmotion.NeuralRegenRes.2014;9(12):1204-1209.欲获更多资讯：NeuralRegenResImplanting1251seedsintoratDRGforneuropathicpain:onlyneuronalmicrodamageoccursTheuseofiodine・125(1251)i
5、ncancertreatmenthasbeenshowntorelievepatients'pain.Consideringdorsalrootgangliaarecriticalforneuraltransmissionbetweentheperipheralandcentralnervoussystems,Dr.TengdaZhan呂andcolleaguesfromInstituteofRadiationMedicine,ChineseAcademyofMedicalSciences,Chin
6、aassumedthat1251couldbeimplantedintoratdorsalrootganglia(DRG)toprovidereliefforneuropathicpain.1251seedswithdifferentradioactivity(0,14.8,29.6MBq)SICENCE新闻发布作者：张腾达稿号:NRR_189_14wereimplantedseparatelyintothevicinityoftheL5DRG.Experimentalresultsshowedth
7、atthemechanicalpainthresholdwaselevatedafterimplanting1251seedswithoutinfluencingmotorfunctionsofthehindlimb,althoughcellinjurywaspresent.ThisarticleisreleasedintheNeuralRegenerationResearch(Vol.9,No.12,2014).Myelinsheathscollapsedandthenumberofmitocho
8、ndriawasreducedinnervefibersat1,440hoursafterimplanting29.6MBqiodine・125seeds.Article:"Implantingiodine・125seedsintoratdorsalrootganglionforneuropathicpain:neuronalmicrodamagewithoutimpactinghindlimbmotion畀byLingJiaol,TengdaZhangl,Wenti
