奥硝唑局部应用对牙周炎患者血清及龈沟液骨代谢及炎性指标的影响-论文.pdf

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1、海南医学院学报2014，20(5)704JournalofHainanMedicalUniversityDOI：10．13210／j．cnki．jhmu．20140124．092网络出版地址：http：／／www．enki．net／kcms／doi／lO．13210／j．enki．jhmu．20140124．092．html奥硝唑局部应用对牙周炎患者血清及龈沟液骨代谢及炎性指标的影响何珍，雷志敏(1．武汉大学人民医院口腔科，湖北武汉430060；2．鄂卅I市中心医院口腔科，湖北鄂州436000)[摘要]目的：研究奥硝唑局部应

2、用对牙周炎患者血清及龈沟液骨代谢及炎性指标的影响。方法：选取本院收治的50例牙周炎患者为研究对象，将其随机分为对照组(替硝唑局部应用组)25例和观察组(奥硝唑局部应用组)25例，然后将两组治疗前后的血清及龈沟液骨代谢及炎性指标进行检测与比较。结果：观察组治疗后2周及4周的血清及龈沟液炎性指标均低于对照组，血清及龈沟液骨代谢指标则均高于对照组，差异具有统计学意义(P<0．05)。结论：奥硝唑局部应用对牙周炎患者血清及龈沟液骨代谢及炎性指标的影响更为积极，对于疾病的控制作用更好。[关键词]奥硝唑；牙周炎；龈沟液；骨代谢指标；炎性

3、指标[中图分类号]R781．4[文献标识码]B[文章编号]1007—1237(2014)05—0704—03EfectsoflocalapplicationofornidazoleonbonemetabolisminserumandgingivalcrevicularfluidandinflammatoryindexesofpatientswithparodontitisHEZhen。LEIZhi—min(DepartmentofStomatology，People'sHospitalofWuhanUniversity，Wu

4、han430060；2Depart—mentofStomatology，EzhouCentralHospital，Ezhou436000，China)EFoundationP，]：FundedbyHubeiProvincialHealth(grantNo．c217622)[Author]：HEZhen(1981一)，Female，EzhouHubei，M．B．，AttendingPhysician，Tel：13545403608，E-mail：hezhendr@163．com．Received：2013—12—27Revis

5、ed：2O14—01—03JHMC，2014；20(5)：704—706Viewfromspecialist：ItiScreative，andofcertainscientificandeducationalvalue．[ABSTRACT]Objective：Tostudytheinfluenceoflocalapplicationofornidazoleonbonemetabolisminserumandgingivalcrevicularfluidandinflammatoryindexesofpatientswithp

6、arodontitis．Methods：Atotalof50patientswithparodontitisenrolledinourhospitalwereselectedasresearchobject，andtheywererandomlydividedintocontrolgroup(1ocalapplicationoftinidazolegroup，一25cases)andobserva—tiongroup(1ocaIapplicationofornidazolegroup，一25cases)，thenboneme

7、tabolismindexesinserumandgingivalcrevicularfluidandinflammatoryindexesoftwogroupsbeforeandafterthetreatmentweredetec—tedandcompared．Results：Twoandfourweeksaftertreatment，bonemetabolismindexesinserumandgingivalcrevicularfluidandinflammatoryindexeswerealllowerthantho

8、seofcontrolgroup(P<0．05)．Conclusion：Localapplicationofornidazoleismoreeffectiveonbonemetabolismindexesinserumandgin—givalcrevieularfluidandinflam