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时间:2020-04-24
《右美托咪定滴鼻预处理对全麻诱导期依托咪酯不良反应的影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第34卷第3期赣南医学院学报f.34NO.32014年6月JOURNALOFGANNANMEDICALUNIVERSII、YjUN.2014右美托咪定滴鼻预处理对全麻诱导期依托咪酯不良反应的影响陈金仙,顾晓霞,蔡树云,刘奕君,杨引(广东医学院附属医院麻醉科,广东湛江524001)摘要:目的:观察右美托咪定术前滴鼻预处理对预防全身麻醉诱导期依托咪酯注射痛及肌阵挛的影响。方法:6O例择期全麻手术者随机分为右美托咪定组(D组)和对照组(N组),各30例。D组术前30min鼻内滴入右美托咪定(1.0txg·kg);N组术前30rain鼻内滴入同等剂量0.9%氯化钠溶液。麻醉诱导时每组均静注
2、依托咪酯0.3mg·kg~。记录两组预给药前(1ro)、给依托咪酯前(T)及给依托咪酯后1rain(rr,)、2min(T)的血压(BP)、心率(HR)、血氧饱合度(SPO);采用词语等级评分法(VRS)评估依托咪酯注射痛;观察并记录静注依托咪酯后2min内肌阵挛发生情况。结果:与T。比较,D组HR、MAP在T,、1r2、明显降低(P均<0.05),N组T,、明显降低(P均<0.05);D组HR在TI、T2、T3较N组降低(P均<0。05)。D组MAP、SPO在T、T2、rr1时点较N组稍降低(P均>0.05);D组肌阵挛各级发生率均较N组降低(P均<0.05);与N组比较,D组依
3、托咪酯注射痛的发生率和严重程度均明显降低(P<0.05)。结论:右美托咪定术前鼻内滴注,能有效减轻麻醉诱导期依托咪酯注射痛,还可减少依托咪酯诱导所致肌阵挛的发生,提供更稳定的血流动力环境。关键词:滴鼻预处理;右美托咪定;依托咪酯;肌阵挛;注射痛中图分类号:R971.2文献标志码:A文章编号:1001—5779(2014)03—0381—03EfectsofintranasaldexmedetomidinepretreatmentoninductionofgeneralanesthesiawithetomidateCHENJin—xian,GUXiao·xia,CAIShu—yun,
4、etal(DepartmentofAnesthesiology,theAffiliatedHospitalofGuangdongMedicalCollege,Zhanjiang,Guangdong524001)Abstract:Objective:Toinvestigatetheeffectsofetomidateinjectionpainandmyoclonusgivenintranasaldexmedetomi—dinepremedicationontheinductionofgereralanesthesia.Methods:Sixtycasesundergoneoperat
5、ionwererandomlyallo—catedtoeachgroup.Intranasaladministrateddexmedetomidine1.0g·kg(groupDn=30)orgivensamevolumeofsaline(groupNn=30)30rainbeforesurgery.Bloodpressure(BP),heartrate(HR),oxygensaturation(SPO2)wererecordedbeforedrug(To),toetomidatebefore(T1)andto1min(T2)、2min(T3)afteretomidate.Scor
6、ingmethodusedwords(VRS)foretomidateinjectionpainscore;observedandrecordedmyoclonusoccurrencewithin2minafterin—travenousetomidate.Results:Therewerenodifferencesbetweentwogroupsinallindexesbeforedrug(P>0.05).TheSBP,HR,theVRSscoresandmyoclonusoccurrenceofgroupDweresignificantlylowerthanthatofgrou
7、pNafterdrug(P<0.05).SP02hadnostatisticalsignificancebetweenthetwogroupsbeforeandafterdrug(P>0.05).Conclusions:Theseresultssuggestthattheintranasaladministrationofdexmedetomidineinpatientsbeforeoperationisasafeandeffec—tirepreoperationme
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