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1、酪酸梭菌二联活菌散辅助治疗小儿肺炎继发性腹泻78例疗效观察【摘耍】目的：探讨酪酸梭菌二联活菌散辅助治疗小儿肺炎继发性腹泻的临床疗效。方法：选取2013年1月-2014年5月本院收治的78例肺炎继发性腹泻患儿，按照随机数字表法将其分为对照组和观察组各39例，对照组给予蒙脱石散(思密达)，观察组在思密达治疗的基础上给予酪酸梭菌二联活菌散，观察比较两组患儿的腹泻持续时间、肺炎治疗疗程、住院时间和治疗效果的差异。结果：观察组的腹泻持续时间、肺炎治疗疗程和住院时间均明显短于对照组，且治疗总有效率94.9%(37/39)明显高于对照组的69
2、.2%(27/39),差异均有统计学意义(P〈0.05)。结论：酪酸梭菌二联活菌散辅助治疗小儿肺炎继发性腹泻疗效确切，可有效修复肠黏膜屏障，迅速缓解腹泻症状，缩短肺炎疗程，值得临床广泛推广使用。【关键词】酪酸梭菌二联活菌散；思密达；肺炎；腹泻ClinicalObservationofClostridiumButyricumPowderfortheAdjuvantTreatmentof78CaseswithChildrenPneumonicSecondaryDiarrhea/JIANGMan,CAISu-fen,KANGHui./
3、/MedicalInnovationofChina,2014,11(28)：054-056【Abstract]Objective：Toinvestigatetheclinicalefficacyofclostridiumbutyricumpowderfortheadjuvanttreatmentofchildrenpneumonicsecondarydiarrhea.Method:78caseswithchildrenpneuinonicsecondarydiarrheainou】hospitalfromJanuary2013t
4、oMay2014wereselected,theyweredividedintothecontrolgroupandtheobservationgroupaccordingt.otherandomnumbertablemethod,39casesineachgroup.Thecontrolgroupwastreatedwithsmecta,andtheobservationgroupwastreatedwithclostridiumbutyricumpowdercombinedwithsmecta.Thediarrheadura
5、tiontime,treatmenttime,lengthofstayandtreatmenteffectoftwogroupswerecompared・Result.：Thediarrheadurationtime,treatmenttime,1engthofstayofobservationgroupweresignificantlyshorterthanthoseofcontrolgroup,thetotaleffectiverateofobservationgroupwas94.9%(37/39),itwassignif
6、icantlyhigherthan69.2%(27/39)ofcontrolgroup,thedifferenceswerestatisticallysignificant(P<0.05)・Conclusion：Clostridiumbutyricumpowderfortheadjuvanttreatmentofchi1drenpneumonicsecondarydiarrheahasexacteffect,itcaneffectivelyrepairintestinalmucosalbarrier,rapidlyrelieve
7、di且rrheasymplomsandshortenthecourseofpneumonia,isworthyofclinicalwidelyused・[Keywords]Clostridiumbutyricumpowder；Smecta；Diarrhea；卩neumoniaFirst-author'saddress:Children?sHospitalofJiangxiProvince,Nanchang330006,Chinadoi：10.3969/j.issn.1674-4985.2014.28.019小儿肺炎多由细菌、病毒
8、等微生物感染引起，临床常采用针对性的抗生素或抗病毒药物治疗［1］。但抗菌药物的使用可破坏肠道菌群平衡，导致肠道黏膜糜烂，上皮细胞脱落，主要临床表现为精神不振、呕吐、腹泻、食欲下降、脱水，甚至全身中毒症状［2-3］o本研究以本院收治的78例肺炎继发性腹泻患儿为研究
