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1、中华实验和临床感染病杂志(电子版)2014年8月第8卷第4期ChinJExpClinInfectDis(ElectronicEdition),August2014,Vol.8,No.4·545··临床论著·有症状神经梅毒危险因素Logistic回归分析魏春波伦文辉万钢【摘要】目的探讨发生症状性神经梅毒的危险因素。方法回顾性分析33例确诊的神经梅毒病例，从患者的年龄、性别、有无前期规范治疗、治疗前血清快速血浆反应素环状卡片试验（RPR）滴度、治疗前脑脊液RPR滴度、脑脊液常规、生化、颅内压力等方面，进行回顾性单因素条件Logistic
2、回归分析。结果年龄、性别、治疗前血清RPR滴度、治疗前脑脊液RPR滴度、脑脊液白细胞数、颅内压力等方面差异均无统计学意义；前期规范治疗可以减少症状性神经梅毒的发生，脑脊2液蛋白浓度与症状性神经梅毒的发生显著相关（χ=4.9184，P=0.0266），为该疾病发生的危险因素；且脑脊液蛋白浓度，每升高1个单位，症状性神经梅毒的危险性可增加1.056倍。结论正规的治疗和随访可以减少症状性神经梅毒的发生；在神经梅毒的治疗、随访中，应特别注意脑脊液蛋白浓度的变化，其水平升高可能预示着症状性神经梅毒的发生。【关键词】症状性神经梅毒；危险因素；L
3、ogistic回归分析InvestigationontheriskfactorsofthesymptomaticneurosyphilisbyLogisticregressionanalysis**WEIChunbo,LUNWenhui,WANGang.DepartmentofDermatologyandVenereology,BeijingDitanHospital,CapitalMedicalUniversity,Beijing100015,ChinaCorrespondingauthor:LUNWenhui,Email:lun
4、wenhui@163.com【Abstract】ObjectiveToinvestigateontheriskfactorsofassociationwiththesymptomaticneurosyphilis.MethodsTheclinicaldataof33patientswithneurosyphiliswereanalyzed,retrospectively,includingtheage,sex,standardizedtreatment,serumrapidplasmareagintest(RPR)titerandR
5、PRtiterincerebrospinalfluidbeforetreatment,cerebrospinalfluidroutine,biochemicalandintracranialpressure,etc.ResultsTherewerenosignificantdifferencesinage,gender,serumRPRtiter,RPRtiterincerebrospinalfluidbeforetreatment,cerebrospinalfluidwhitebloodcellcountandintracrani
6、alpressure.Standardizedtreatmentcouldreducetheincidenceofsymptomaticneurosyphilis.Therewasasignificantcorrelationbetweencerebrospinalfluid(CSF)proteinconcentrationandtheincidenceofsymptomaticneurosyphilis2(χ=4.9184，P=0.0266).CSFproteinconcentrationwasariskfactor,andwhe
7、nitincreasesbyoneunit,symptomaticneurosyphiliscouldincreasetheriskof1.056times.ConclusionsRegulartreatmentandfollow-upcouldreducetheincidenceofsymptomaticneurosyphilis.Inthecourseofneurosyphilistherapyandfollow-up,weshouldpayparticularattentiontochangesincerebrospinalf
8、luidproteinconcentration,whichmayindicatetheoccurrenceofsymptomaticneurosyphilis,whenitiselevated.【Keywords】Symptomat
